Compromised mechanical homeostasis in arterial aging and associated cardiovascular consequences.

Biomechanics and Modeling in Mechanobiology
J FerruzziJ D Humphrey

Abstract

Aging leads to central artery stiffening and associated hemodynamic sequelae. Because healthy arteries exhibit differential geometry, composition, and mechanical behaviors along the central vasculature, we sought to determine whether wall structure and mechanical function differ across five vascular regions-the ascending and descending thoracic aorta, suprarenal and infrarenal abdominal aorta, and common carotid artery-in 20 versus 100-week-old male wild-type mice. Notwithstanding generally consistent changes across these regions, including a marked thickening of the arterial wall, diminished in vivo axial stretch, and loss of elastic energy storage capacity, the degree of changes tended to be slightly greater in abdominal than in thoracic or carotid vessels. Likely due to the long half-life of vascular elastin, most mechanical changes in the arterial wall resulted largely from a distributed increase in collagen, including thicker fibers in the media, and localized increases in glycosaminoglycans. Changes within the central arteries associated with significant increases in central pulse pressure and adverse changes in the left ventricle, including increased cardiac mass and decreased diastolic function. Given the similar half-l...Continue Reading

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Citations

Mar 28, 2019·Journal of Biomechanical Engineering·Sonja BrankovicRichard K Assoian
May 27, 2020·Journal of the Royal Society, Interface·S-I MurtadaJ D Humphrey
Oct 12, 2018·Biomechanics and Modeling in Mechanobiology·A KornevaC Bellini
Oct 28, 2019·Scientific Reports·H AhmadzadehJ D Humphrey
Jul 6, 2018·Current Hypertension Reports·Korshie DumorAdam Whaley-Connell
Feb 15, 2019·Proceedings. Mathematical, Physical, and Engineering Sciences·Federica CuomoC Alberto Figueroa
Oct 21, 2020·PLoS Computational Biology·M Latorre, J D Humphrey
Oct 10, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Jie Z HawesJessica E Wagenseil
Dec 30, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Shana R WatsonSusan M Lessner
Mar 9, 2021·Biomechanics and Modeling in Mechanobiology·Alberto CoccarelliSanjay Pant
Mar 21, 2021·Mechanisms of Ageing and Development·Cristina CavinatoJay D Humphrey
Jul 3, 2021·Jornal Vascular Brasileiro·Adenauer Marinho de Oliveira GóesWaldonio de Brito Vieira

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