Compromised microvascular oxygen delivery increases brain tissue vulnerability with age

Scientific Reports
Mohammad MoeiniFrédéric Lesage

Abstract

Despite the possible role of impaired cerebral tissue oxygenation in age-related cognition decline, much is still unknown about the changes in brain tissue pO2 with age. Using a detailed investigation of the age-related changes in cerebral tissue oxygenation in the barrel cortex of healthy, awake aged mice, we demonstrate decreased arteriolar and tissue pO2 with age. These changes are exacerbated after middle-age. We further uncovered evidence of the presence of hypoxic micro-pockets in the cortex of awake old mice. Our data suggests that from young to middle-age, a well-regulated capillary oxygen supply maintains the oxygen availability in cerebral tissue, despite decreased tissue pO2 next to arterioles. After middle-age, due to decreased hematocrit, reduced capillary density and higher capillary transit time heterogeneity, the capillary network fails to compensate for larger decreases in arterial pO2. The substantial decrease in brain tissue pO2, and the presence of hypoxic micro-pockets after middle-age are of significant importance, as these factors may be related to cognitive decline in elderly people.

References

Dec 1, 1992·The American Journal of Physiology·A R PriesP Gaehtgens
Oct 1, 1992·International Journal of Sports Medicine·T F Hornbein
Jan 1, 1991·Advances in Experimental Medicine and Biology·M SamajaM Tarantola
Jul 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A J MartinR S Frackowiak
Dec 1, 1990·Journal of Experimental Psychology. General·T O NelsonD Anderson
Jan 1, 1990·Respiration Physiology·M SamajaP E diPrampero
Mar 1, 1989·The American Journal of Physiology·M I Talan, B T Engel
Jun 1, 1985·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A Gjedde, N H Diemer
Oct 1, 1967·The Journal of Clinical Investigation·M J Edwards, D A Rigas
Jul 1, 1984·Stroke; a Journal of Cerebral Circulation·P PantanoD Comar
Sep 1, 1980·Mechanisms of Ageing and Development·W Meier-RugeA Schweizer
Jun 1, 1981·Brain : a Journal of Neurology·M OhataS I Rapoport
May 1, 1981·The International Journal of Applied Radiation and Isotopes·H F Moustafa, J W Hopewell
Nov 1, 1981·Neuropathology and Applied Neurobiology·J H WilkinsonH S Reinhold
Jul 1, 1995·Neuropsychologia·F EustacheJ C Baron
Nov 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C HockA Villringer
Jul 1, 1995·Hypertension·D P VeermanG A van Montfrans
Mar 1, 1993·The American Journal of Physiology·I LartaudC Capdeville-Atkinson
Jul 1, 1996·Psychological Review·T A Salthouse
Aug 1, 1997·American Journal of Respiratory and Critical Care Medicine·J CardúsP D Wagner
Jan 1, 1996·Pharmacology & Therapeutics·R N Kalaria
Dec 2, 2000·Journal of the Neurological Sciences·M BentourkiaA G De Volder
Apr 20, 2001·Progress in Neurobiology·E Farkas, P G Luiten
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·Y NakaoL Sokoloff
Feb 28, 2003·Ageing Research Reviews·David R RiddleRobin J Lichtenwalner
Aug 19, 2003·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Alicia VillenaIgnacio Pérez De Vargas
Apr 23, 2005·Organic Letters·Sergei A Vinogradov
Jul 19, 2005·Neurobiology of Aging·M J HerrmannA J Fallgatter
Dec 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Nozomi NishimuraDavid Kleinfeld
Aug 21, 2007·Essays in Biochemistry·Chris PeersJohn P Boyle
Jan 1, 2008·Journal of Biomedical Optics·Rodolfo GattoFady Charbel
May 29, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Maithili SharanRoland N Pittman
Jul 30, 2008·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Olga S FinikovaSergei A Vinogradov
Mar 11, 2009·Brain Research·Katja BertschEwald Naumann

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Citations

Dec 6, 2018·Journal of Biomedical Optics·İkbal ŞencanSava Sakadžić
Jan 7, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ben Schager, Craig E Brown
Oct 17, 2019·Annual Review of Physiology·T Michael De Silva, Frank M Faraci
Apr 3, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Şefik E ErdenerDavid A Boas
Jun 10, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·İkbal ŞencanSava Sakadžić
Jan 31, 2019·American Journal of Hematology·Yaqiong ChaiJohn C Wood
Aug 10, 2020·Scientific Reports·Mohammad MoeiniFrédéric Lesage
Dec 10, 2020·ESC Heart Failure·Isabella KharrazihaViktor Hamrefors
Jan 29, 2021·PLoS Computational Biology·Grant HartungAndreas Linninger
Nov 13, 2020·Frontiers in Physiology·David F Wilson, Franz M Matschinsky
Mar 30, 2021·Anesthesia and Analgesia·Brina SnyderThomas F Floyd
Apr 29, 2021·Cell Reports·Michael R WilliamsonTheresa A Jones
Jun 26, 2021·PLoS Computational Biology·Jonathan P Alberding, Timothy W Secomb
Jul 11, 2021·Scientific Reports·Rafat DamsehFrederic Lesage
Jul 28, 2021·Rejuvenation Research·James W LarrickAndrew R Mendelsohn
Dec 17, 2021·Nature Communications·Florian GoirandSylvie Lorthois

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Methods Mentioned

BETA
fluorescence microscopy
phosphorescence

Software Mentioned

Python
RMSprop
Matlab
Theano

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