Computational analysis of glenohumeral joint growth and morphology following a brachial plexus birth injury

Journal of Biomechanics
Nikhil N DixitKatherine R Saul

Abstract

Children affected with brachial plexus birth injury (BPBI) undergo muscle paralysis. About 33% of affected children experience permanent osseous deformities of the glenohumeral joint. Recent evidence suggests that some cases experience restricted muscle longitudinal growth in addition to paralysis and reduced range of motion at the shoulder and elbow. It is unknown whether altered loading due to paralysis, muscle growth restriction and contracture, or static loading due to disuse is the primary driver of joint deformity after BPBI. This study uses a computational framework integrating finite element analysis and musculoskeletal modeling to examine the mechanical factors contributing to changes in bone growth and morphometry following BPBI. Simulations of 8 weeks of glenohumeral growth in a rat model of BPBI predicted that static loading of the joint is primarily responsible for joint deformation consistent with experimental measures of bone morphology, whereas dynamic loads resulted in normal bone growth. Under dynamic loading, glenoid version angle (GVA), glenoid inclination angle (GIA), and glenoid radius of curvature (GRC) (-1.3°, 38.2°, 2.5 mm respectively) were similar to the baseline values (-1.8°, -38°, 2.1 mm respective...Continue Reading

Citations

Sep 14, 2020·The Journal of Hand Surgery·Nikhil N DixitKatherine R Saul
Dec 29, 2020·The Journal of Hand Surgery·Nikhil N DixitKatherine R Saul
Jul 31, 2021·Bone·S Mahsa SadeghianSandra J Shefelbine
Jul 7, 2021·Journal of Biomechanical Engineering·Danielle HoweMatthew B Fisher

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