Computational analysis of the productivity potential of CAM

Nature Plants
Sanu ShameerLee J Sweetlove

Abstract

There is considerable interest in transferring crassulacean acid metabolism (CAM) to C3 crops to improve their water-use efficiency. However, because the CAM biochemical cycle is energetically costly, it is unclear what impact this would have on yield. Using diel flux balance analysis of the CAM and C3 leaf metabolic networks, we show that energy consumption is three-fold higher in CAM at night. However, this additional cost of CAM can be entirely offset by the carbon-concentrating effect of malate decarboxylation behind closed stomata during the day. Depending on the resultant rates of the carboxylase and oxygenase activities of rubisco, the productivity of the PEPCK-CAM subtype is 74-100% of the C3 network. We conclude that CAM does not impose a significant productivity penalty and that engineering CAM into C3 crops is likely to lead to a major increase in water-use efficiency without substantially affecting yield.

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Citations

Jun 30, 2018·PloS One·Samantha HartzellAmilcare Porporato
Apr 12, 2019·Journal of Experimental Botany·Nathalie CeustersJohan Ceusters
Jan 17, 2020·The Plant Journal : for Cell and Molecular Biology·Methawi Chomthong, Howard Griffiths
Jan 28, 2020·The Plant Journal : for Cell and Molecular Biology·Sanu ShameerLee J Sweetlove
Oct 20, 2020·Plant, Cell & Environment·Samantha HartzellAmilcare Porporato
Jan 26, 2021·Biochemical Society Transactions·Nadine Töpfer
Oct 19, 2020·The Plant Journal : for Cell and Molecular Biology·X L Joshua Tan, C Y Maurice Cheung
Jul 10, 2019·Current Opinion in Plant Biology·Nicholas A NiechayevJohn C Cushman
Jul 9, 2020·Progress in Lipid Research·Sandra M CorreaYariv Brotman
Aug 7, 2018·Plant Science : an International Journal of Experimental Plant Biology·Degao LiuXiaohan Yang
May 6, 2021·Cellular and Molecular Life Sciences : CMLS·Hao TongZoran Nikoloski
Dec 9, 2020·Functional Plant Biology : FPB·Klaus WinterJ Andrew C Smith
Apr 14, 2021·Annual Review of Plant Biology·Katharina Schiller, Andrea Bräutigam
Apr 14, 2021·Annual Review of Plant Biology·Hiroshi A Maeda, Alisdair R Fernie
Sep 3, 2021·Computational and Structural Biotechnology Journal·Ankur SahuNadine Töpfer
Oct 13, 2021·The New Phytologist·Klaus Winter, J Andrew C Smith
Oct 27, 2021·The Plant Journal : for Cell and Molecular Biology·Sanu ShameerLee J Sweetlove

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Software Mentioned

COBRApy
Agave
ChemAxon
JavaCyc
Pathway Tools
Met4J
GLPK

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