Computational and analytical challenges in single-cell transcriptomics

Nature Reviews. Genetics
Oliver StegleJohn C Marioni

Abstract

The development of high-throughput RNA sequencing (RNA-seq) at the single-cell level has already led to profound new discoveries in biology, ranging from the identification of novel cell types to the study of global patterns of stochastic gene expression. Alongside the technological breakthroughs that have facilitated the large-scale generation of single-cell transcriptomic data, it is important to consider the specific computational and analytical challenges that still have to be overcome. Although some tools for analysing RNA-seq data from bulk cell populations can be readily applied to single-cell RNA-seq data, many new computational strategies are required to fully exploit this data type and to enable a comprehensive yet detailed study of gene expression at the single-cell level.

References

Feb 11, 1994·Science·M ChalfieD C Prasher
Aug 30, 2000·Nature·Charles M PerouDavid Botstein
Jul 27, 2001·Bioinformatics·Dana Pe'erNir Friedman
Feb 2, 2002·Nature·Laura J van 't VeerStephen H Friend
Dec 16, 2003·Proceedings of the National Academy of Sciences of the United States of America·James C LiaoVwani P Roychowdhury
May 11, 2005·Nature Reviews. Genetics·Mads KaernJames J Collins
Oct 20, 2006·PLoS Biology·Arjun RajSanjay Tyagi
Feb 15, 2007·Molecular Systems Biology·Mukesh BansalDiego di Bernardo
Oct 3, 2007·PLoS Genetics·Jeffrey T Leek, John D Storey
Dec 15, 2007·Biostatistics·Jerome FriedmanRobert Tibshirani
May 3, 2008·Science·Ugrappa NagalakshmiMichael Snyder
Jun 3, 2008·Nature Methods·Ali MortazaviBarbara Wold
Sep 23, 2008·Nature Methods·Arjun RajSanjay Tyagi
Oct 30, 2008·Cell·Arjun Raj, Alexander van Oudenaarden
Nov 19, 2008·Nature Reviews. Genetics·Zhong WangMichael Snyder
Mar 18, 2009·Bioinformatics·Cole TrapnellSteven L Salzberg
Apr 8, 2009·Nature Methods·Fuchou TangM Azim Surani
Jun 16, 2009·Nature Methods·Kiyomi TaniguchiHideki Kambara
Feb 12, 2010·Bioinformatics·Thomas D Wu, Serban Nacu
Mar 4, 2010·Genome Biology·Mark D Robinson, Alicia Oshlack
Mar 12, 2010·Nature·Joseph K PickrellJonathan K Pritchard
Apr 1, 2010·Genome Research·C Joel McManusPatricia J Wittkopp
Aug 12, 2010·BMC Bioinformatics·Thomas J Hardcastle, Krystyna A Kelly
Oct 29, 2010·Genome Biology·Simon Anders, Wolfgang Huber
Nov 9, 2010·Nature Methods·Yarden KatzChristopher B Burge
Dec 24, 2010·Genome Biology·Alicia OshlackMatthew D Young
Jan 12, 2011·Nature Biotechnology·James T RobinsonJill P Mesirov
Jan 27, 2011·PLoS Biology·Graciana Diez-RouxAndrea Ballabio
May 20, 2011·Nature·Björn SchwanhäusserMatthias Selbach
Aug 6, 2011·Genome Research·Lichun JiangBrian Oliver
Aug 25, 2011·Current Opinion in Genetics & Development·Daniel R Larson
Oct 21, 2011·Nature·David BrawandHenrik Kaessmann
Jan 12, 2012·Proceedings of the National Academy of Sciences of the United States of America·Luis B BarreiroYoav Gilad
Apr 14, 2012·Science·Brian MunskyAlexander van Oudenaarden
Apr 21, 2012·Briefings in Bioinformatics·Helga ThorvaldsdóttirJill P Mesirov
Jun 23, 2012·Genome Research·Simon AndersWolfgang Huber
Jul 24, 2012·Nature Biotechnology·Daniel RamsköldRickard Sandberg
Sep 4, 2012·Cell Reports·Tamar HashimshonyItai Yanai
Sep 8, 2012·Nature·ENCODE Project Consortium
Oct 2, 2012·Cell·Charles Y LinRichard A Young
Oct 13, 2012·Bioinformatics·Nuno A FonsecaJohn C Marioni
Oct 30, 2012·Cell·Jakob LovénRichard A Young
Jan 31, 2013·Genome Biology·Jong Kyoung Kim, John C Marioni
Jul 3, 2013·Methods : a Companion to Methods in Enzymology·Matthew P A DavisAnton J Enright
Jul 31, 2013·Nature Reviews. Genetics·Ehud ShapiroSten Linnarsson
Sep 24, 2013·Nature Methods·Simone PicelliRickard Sandberg
Sep 24, 2013·Nature Methods·Philip BrenneckeMarcus G Heisler
Oct 22, 2013·Nature Methods·Angela R WuStephen Quake
Dec 24, 2013·Nature Methods·Saiful IslamSten Linnarsson
Mar 1, 2014·Science·Je Hyuk LeeGeorge M Church
Apr 22, 2014·Nature Methods·Dominic GrünAlexander van Oudenaarden
May 20, 2014·Nature Methods·Peter V KharchenkoDavid T Scadden
Jun 14, 2014·Science·Anoop P PatelBradley E Bernstein
Aug 26, 2014·Nature Biotechnology·Davide RissoSandrine Dudoit
Sep 26, 2014·PLoS Computational Biology·Jean-Baptiste PettitJohn C Marioni
Sep 28, 2014·Bioinformatics·Simon AndersWolfgang Huber

Citations

Nov 25, 2015·Expert Review of Molecular Diagnostics·Mireia Mato PradoJonathan Krell
Nov 10, 2015·Immunology·Valentina Proserpio, Bidesh Mahata
Jan 25, 2016·Current Opinion in Genetics & Development·Celia Pilar Martinez-Jimenez, Duncan T Odom
Nov 17, 2015·International Journal of Molecular Sciences·Kjetil Hodne, Finn-Arne Weltzien
Dec 22, 2015·Current Opinion in Neurobiology·Andrew E Jaffe
Jan 28, 2016·Genome Biology·Ana ConesaAli Mortazavi
Jan 11, 2016·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Lise J HarbomMichael J McConnell
Sep 27, 2015·The Plant Journal : for Cell and Molecular Biology·Nobuhiro SuzukiRon Mittler
Nov 19, 2015·Immunology and Cell Biology·Steven WoodhouseJasmin Fisher
Feb 11, 2016·Immunology and Cell Biology·Auda A EltahlaFabio Luciani
Oct 3, 2015·Cell Stem Cell·Aleksandra A KolodziejczykSarah A Teichmann
Mar 24, 2016·Experimental Neurology·Karen C DietzFraser J Sim
Mar 24, 2016·BMC Bioinformatics·Justina Žurauskienė, Christopher Yau
Mar 26, 2016·Cell·Mubeen GoolamMagdalena Zernicka-Goetz
Mar 1, 2016·Expert Review of Proteomics·Haloom RafehiAssam El-Osta
Nov 4, 2015·Immunology and Cell Biology·Ana Cvejic
Oct 10, 2015·Trends in Genetics : TIG·Assieh SaadatpourGuo-Cheng Yuan
Apr 8, 2016·Genome Biology·Rhonda Bacher, Christina Kendziorski
Aug 20, 2015·Nature·Lu Wen, Fuchou Tang
Mar 27, 2015·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jason A MorrisonPaul M Kulesa
Jul 6, 2015·Methods : a Companion to Methods in Enzymology·Antonio ScialdoneFlorian Buettner
Apr 17, 2016·Genome Biology·Lu Wen, Fuchou Tang
Apr 19, 2016·Nature Methods·Hamim ZafarKen Chen
May 23, 2015·Molecular Cell·Aleksandra A KolodziejczykSarah A Teichmann
Apr 14, 2015·Nature Biotechnology·Kaia AchimJohn C Marioni
May 7, 2016·Bioinformatics·Peng JiangRon Stewart
Apr 27, 2016·Current Opinion in Biotechnology·Deborah ChasmanSushmita Roy
May 8, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Allison R GreenplateJonathan M Irish
May 11, 2016·Genome Biology·Sten Linnarsson, Sarah A Teichmann
May 12, 2016·Genome Biology·Megan CrowJesse Gillis
May 18, 2016·Biochimica Et Biophysica Acta·Julie MassartAnna Krook
May 21, 2016·Wiley Interdisciplinary Reviews. RNA·Radmila HrdlickovaBin Tian
May 22, 2016·Nucleic Acids Research·Gregory GiecoldGuo-Cheng Yuan
Jun 17, 2016·Current Opinion in Immunology·Kai W Wucherpfennig, Adam Nr Cartwright
Jun 19, 2016·Genome Biology·Yujiao DangJie Qiao
Jun 21, 2016·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Vladimir Espinosa Angarica, Antonio Del Sol
Jun 25, 2015·PLoS Computational Biology·Catalina A VallejosSylvia Richardson
Jul 5, 2016·Briefings in Bioinformatics·Maria K JaakkolaLaura L Elo
Jul 6, 2016·BMC Bioinformatics·Trevor Clancy, Eivind Hovig
Jul 8, 2016·Nature·Antonio ScialdoneBerthold Göttgens
Jul 15, 2016·Histochemistry and Cell Biology·Arkadiy K GolovAlexey A Gavrilov
Jul 28, 2016·The Journal of Investigative Dermatology·Sarah K WhitleyJay K Kolls
Aug 25, 2016·BMC Genomics·Hung-I Harry ChenYidong Chen
Apr 20, 2016·Annual Review of Genomics and Human Genetics·Matthias Merkenschlager, Elphège P Nora
Sep 13, 2016·Nature Reviews. Genetics·Naomi MorisAlfonso Martinez Arias
Sep 27, 2016·Cell Metabolism·Åsa SegerstolpeRickard Sandberg
Sep 26, 2016·Current Opinion in Cell Biology·Victoria Moignard, Berthold Göttgens
Oct 9, 2016·BMC Bioinformatics·Charles GirardotEileen E M Furlong
Sep 30, 2016·European Journal of Immunology·Robrecht CannoodtYvan Saeys
Nov 7, 2016·Virus Research·Sylvie RatoAngela Ciuffi
Nov 8, 2016·Nature Reviews. Genetics·Detlev ArendtGünter P Wagner
Nov 9, 2016·Nature Biotechnology·Allon WagnerNir Yosef
Jun 5, 2016·FEBS Letters·Fiona K HameyBerthold Göttgens
Sep 12, 2015·Molecular Human Reproduction·Dicle YalcinHasan H Otu
Jan 4, 2017·Scientific Reports·Po-Yuan TungYoav Gilad
Jan 28, 2017·Current Opinion in Genetics & Development·Daphne Tsoucas, Guo-Cheng Yuan
Mar 7, 2017·Nature Methods·Valentine SvenssonSarah A Teichmann
Apr 1, 2017·Science·Celia Pilar Martinez-JimenezDuncan T Odom
Apr 6, 2017·Bioinformatics·Sabrina RashidZiv Bar-Joseph
Jan 28, 2017·Current Opinion in Genetics & Development·Jasper WoutersStein Aerts
Feb 24, 2017·SLAS Discovery·Albert GoughD Lansing Taylor
Jun 2, 2017·Nature Communications·Andrew E Teschendorff, Tariq Enver
Jun 20, 2017·Nature Reviews. Genetics·Simon A HardwickTim R Mercer
Jun 11, 2017·FEBS Letters·Ilaria LungerMichael A Rieger
Jun 6, 2017·Bioinformatics·Nikolaos K ChlisFabian J Theis
Aug 1, 2017·International Journal of Molecular Sciences·Amelia CasamassimiAlfredo Ciccodicola
Jan 25, 2018·Genes·Yuxuan YuanDavid Edwards
Jan 18, 2018·Briefings in Functional Genomics·Mark W E J FiersStein Aerts
Nov 10, 2017·Biostatistics·Stephanie C HicksRafael A Irizarry
Oct 6, 2017·Nucleic Acids Research·Shun H YipJunwen Wang
Apr 21, 2018·Annual Review of Immunology·Alexandra-Chloé VillaniNir Hacohen
Jan 10, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hongping ZhengXin Wei Wang
Nov 9, 2017·Genome Biology·Florian BuettnerOliver Stegle
Nov 11, 2017·Briefings in Functional Genomics·Jeanette Baran-GaleKristina Kirschner
Apr 25, 2018·Bioinformatics·Zhijin WuHao Wu
Dec 28, 2017·Interdisciplinary Sciences, Computational Life Sciences·Lijun Tang, Nan Zhou
Jun 26, 2018·PLoS Computational Biology·Luke ZappiaAlicia Oshlack
Nov 7, 2017·Briefings in Functional Genomics·Mattias Rantalainen
Mar 27, 2018·Briefings in Functional Genomics·Christoph ZiegenhainWolfgang Enard
Dec 19, 2017·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Simone EckerDirk S Paul
Dec 6, 2017·ELife·Aviv RegevHuman Cell Atlas Meeting Participants
Jul 28, 2018·Bioinformatics·Magdalena E StraußLorenz Wernisch
Jul 31, 2018·The FEBS Journal·Helena Todorov, Yvan Saeys
Apr 28, 2018·Circulation Research·Robert C WirkaThomas Quertermous
Jul 16, 2016·Nature Communications·Dewi HarjantoAnastasia Papavasiliou
Mar 8, 2016·F1000Research·Serena Liu, Cole Trapnell
Jun 26, 2018·Bioinformatics·Kieran R Campbell, Christopher Yau
Feb 10, 2018·NPJ Systems Biology and Applications·Sylvie DelhalleFeng Q He
Jan 18, 2018·Integrative Biology : Quantitative Biosciences From Nano to Macro·Chunhe Li
Mar 1, 2019·PLoS Computational Biology·Chiara DamianiGiancarlo Mauri
Oct 13, 2017·Nature·Taru TukiainenDaniel G MacArthur
Oct 11, 2017·Nature Methods·Sara AibarStein Aerts
Feb 8, 2019·Blood·Satyen H Gohil, Catherine J Wu
Apr 6, 2019·Biological Chemistry·Chrysa NikopoulouPeter Tessarz
Aug 30, 2016·Nature Neuroscience·Jean-Francois PoulinRajeshwar Awatramani
Oct 24, 2015·Nature Reviews. Cancer·Thomas J Gonda, Robert G Ramsay
May 8, 2019·Nature Biotechnology·Brian HieBonnie Berger
May 8, 2019·Nature Biotechnology·Aaron M NewmanAsh A Alizadeh
May 12, 2018·Genome Biology·Daphne Tsoucas, Guo-Cheng Yuan
Aug 25, 2017·Nature Reviews. Cancer·Timour Baslan, James Hicks
Dec 12, 2017·Nature Biotechnology·Hyun Min KangChun Jimmie Ye
Jun 22, 2019·Nucleic Acids Research·Jurrian K de KanterFrank C P Holstege
Jun 28, 2019·Briefings in Bioinformatics·Raphael PetegrossoRui Kuang
Jun 18, 2019·American Journal of Reproductive Immunology : AJRI·Jessica VazquezAleksandar K Stanic
Mar 29, 2019·Molecular Systems Biology·Will MacnairManfred Claassen
Sep 11, 2019·Nucleic Acids Research·Eldad David Shulman, Ran Elkon
Nov 7, 2018·Scientific Reports·Divyanshu TalwarAngshul Majumdar
Oct 11, 2019·Bioinformatics·Giacomo BaruzzoBarbara Di Camillo
Jun 16, 2017·Blood·Jacob C UlirschVijay G Sankaran
Oct 23, 2019·Frontiers in Immunology·Patrick Günther, Joachim L Schultze
Dec 13, 2019·Genome Biology·Jose Alquicira-HernandezJoseph E Powell
Mar 16, 2019·Clinical Chemistry·Carmela PaolilloPaolo Fortina
Feb 7, 2020·The Biochemical Journal·Elizabeth A Rondini, James G Granneman
Feb 16, 2020·Journal of Molecular Evolution·David A LiberlesAndrew Storfer
Oct 8, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Chuan Ku, Arnau Sebé-Pedrós
Jan 10, 2020·Physiological Reviews·Anuradha RaySally E Wenzel
Nov 16, 2019·Nature Communications·Kwangbom ChoiGary A Churchill
May 8, 2020·Cell Biology International·Chiranjib ChakrabortyGovindasamy Agoramoorthy
Jun 2, 2020·Nucleic Acids Research·Suluxan MohanrajTrevor J Pugh
May 18, 2020·Bioinformatics·Yang LiuDeyou Zheng
Jul 14, 2020·Bioinformatics·Qiuyu LianKong Chen
Jul 14, 2020·Bioinformatics·Kerem Wainer-Katsir, Michal Linial
May 5, 2020·Bioinformatics·Di RanLingling An
Sep 5, 2019·Nature Cell Biology·Shanshan AiAibin He
Dec 17, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yang ChengEvan W Newell
Jan 8, 2016·Nucleic Acids Research·Joshua D WelchJan F Prins
Nov 23, 2016·Statistical Applications in Genetics and Molecular Biology·Audrey Qiuyan Fu, Lior Pachter
Mar 17, 2017·Annual Review of Analytical Chemistry·Angela R WuYanyi Huang
Jun 8, 2017·Frontiers in Genetics·Alessandra Dal MolinBarbara Di Camillo
May 23, 2017·F1000Research·Belinda PhipsonAlicia Oshlack
Jun 21, 2017·Nature Communications·Zehua LiuTing Chen
Aug 17, 2017·Annual Review of Cell and Developmental Biology·John C Marioni, Detlev Arendt
Jan 30, 2018·PloS One·Michael VanInsbergheCarl L Hansen
May 3, 2018·Nucleic Acids Research·Liang Chen, Sika Zheng
Jun 10, 2018·BMC Bioinformatics·Wuming GongDaniel J Garry
Jun 28, 2018·Proceedings of the National Academy of Sciences of the United States of America·Jingshu WangNancy R Zhang
May 24, 2018·Nature Reviews. Nephrology·S Steven Potter
Aug 30, 2018·Nature Reviews. Genetics·Darren J Burgess
Aug 12, 2018·Genome Biology·Ángeles Arzalluz-Luque, Ana Conesa
Nov 9, 2018·Genome Biology·Jennifer WestobyMartin Hemberg
Oct 23, 2018·Frontiers in Oncology·Francesca Finotello, Federica Eduati
Nov 8, 2018·BMC Genomics·M Senthil KumarHéctor Corrada Bravo
Dec 14, 2018·Frontiers in Cardiovascular Medicine·Andrea MassaiaMichela Noseda
May 28, 2019·Frontiers in Molecular Neuroscience·Lin QueCsaba Földy
Jun 15, 2019·Nature Communications·Xiuwei ZhangNir Yosef
Aug 1, 2019·Nature Reviews. Immunology·Luke FrankiwGuideng Li
Jul 26, 2019·Nature Reviews. Genetics·Rory StarkJames Hadfield
Nov 7, 2019·World Journal of Stem Cells·Xiao Zhang, Lei Liu
Jan 21, 2020·Genome Biology·Koki TsuyuzakiItoshi Nikaido
Feb 9, 2020·Genome Biology·David LähnemannAlexander Schönhuth
Mar 3, 2020·Frontiers in Genetics·Xiaonan YangYang Dong
May 9, 2020·Communications Biology·Maeve O'HuallachainGarry P Nolan
Jul 14, 2020·ELife·Nathan E Reticker-Flynn, Edgar G Engleman
Apr 28, 2017·Genome Biology·Yuchao JiangMingyao Li
Jun 10, 2017·Clinical and Translational Medicine·Raquel Cuevas-Diaz DuranJia Qian Wu
Feb 14, 2018·Development·Sam BehjatiMuzlifah Haniffa
Feb 20, 2018·Frontiers in Neuroscience·Hyobin Jeong, Vijay K Tiwari
Aug 8, 2018·Nature Communications·Bo WangJure Leskovec
Feb 8, 2019·Biophysics Reviews·Christopher Yau, Kieran R Campbell
Mar 22, 2019·Scientific Reports·Shambhavi SinghKevin A Janes
Oct 18, 2019·Nature Reviews. Clinical Oncology·James T YurkovichLeroy Hood
Apr 2, 2020·Nature Reviews. Cardiology·David T PaikJoseph C Wu
Apr 11, 2020·Quantitative Biology·Md Bahadur BadshaAudrey Qiuyan Fu
Jul 8, 2020·Nature Methods·Kenneth H HuMatthew F Krummel
Mar 12, 2020·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Enrico BorrielloManfred D Laubichler
Mar 3, 2020·Frontiers in Genetics·Nicholas LytalLingling An
Aug 19, 2020·Nature Immunology·Juan M Inclan-RicoMark C Siracusa
Sep 16, 2020·Experimental & Molecular Medicine·Jean FanFan Zhang
Sep 23, 2020·Life Science Alliance·Andreas Fønss Møller, Kedar Nath Natarajan
Aug 29, 2020·Nature Communications·Sarah Aldridge, Sarah A Teichmann
May 5, 2017·G3 : Genes - Genomes - Genetics·Bo DingWei Wang
Jan 13, 2017·Briefings in Bioinformatics·Sipko van DamJoão Pedro de Magalhães
Jun 1, 2018·Current Protocols in Molecular Biology·Thale Kristin Olsen, Ninib Baryawno
May 12, 2018·Diagnostics·Francesc Castro-GinerNicola Aceto
Feb 3, 2018·Briefings in Bioinformatics·Alessandra Dal Molin, Barbara Di Camillo
Sep 2, 2018·Nature Methods·J Gray CampBarbara Treutlein
Jan 27, 2019·PloS One·Shannon R McCurdyLior Pachter
Nov 30, 2018·Nucleic Acids Research·Cheryl StorkSika Zheng
Nov 8, 2018·Disease Models & Mechanisms·Paulina M StrzeleckaAna Cvejic
Apr 30, 2019·Frontiers in Genetics·Abhijeet R SonawaneAmitabh Sharma
Apr 27, 2019·Frontiers in Genetics·Geng ChenTieliu Shi
Sep 14, 2019·Nature Reviews. Genetics·Francesca FinotelloZlatko Trajanoski
Jan 25, 2019·Nature Communications·Gökcen EraslanFabian J Theis
Mar 14, 2019·Nucleic Acids Research·Hao DaiLuonan Chen
Mar 21, 2020·Frontiers in Bioengineering and Biotechnology·Quan ChengSong-Shan Feng
Jun 27, 2019·Current Protocols in Molecular Biology·Fei Ji, Ruslan I Sadreyev
May 10, 2020·Inflammatory Bowel Diseases·Daniele CorridoniAlison Simmons
Apr 23, 2020·Frontiers in Oncology·Guillermo de Anda-Jáuregui, Enrique Hernández-Lemus
Aug 10, 2020·Genome Biology·Chenfei WangX Shirley Liu
Apr 27, 2020·BMC Bioinformatics·Rui Dong, Guo-Cheng Yuan
May 20, 2017·FEBS Letters·Raghd RostomGozde Kar
May 3, 2016·Nature Biotechnology·Manu SettyDana Pe'er
Jan 23, 2017·Journal of Hematology & Oncology·Fang YeGuoji Guo
Aug 24, 2018·Briefings in Bioinformatics·Taiyun KimPengyi Yang
Dec 15, 2018·BMC Systems Biology·Mary Qu YangRenchu Guan
May 9, 2019·Nature Reviews. Rheumatology·Peggie CheungAlex J Kuo
Sep 11, 2019·Bioinformatics·Abha S Bais, Dennis Kostka
Jan 9, 2019·Nature Reviews. Genetics·Vladimir Yu KiselevMartin Hemberg
Jan 11, 2020·Frontiers in Cardiovascular Medicine·Farhan ChaudhryPhillip D Levy
May 16, 2019·Journal of Translational Medicine·Laura Bravo-MerodioAnimesh Acharjee
Jan 1, 2019·Reproduction, Fertility, and Development·Rocío Melissa Rivera
Oct 22, 2019·European Journal of Immunology·Andrea CossarizzaArturo Zychlinsky
Jan 12, 2020·Briefings in Bioinformatics·Meichen DongYuchao Jiang
Jun 18, 2017·Frontiers in Genetics·Sören Müller, Aaron Diaz
May 16, 2017·Nature Methods·Catalina A VallejosJohn C Marioni
Oct 8, 2017·Scientific Reports·Simone RizzettoFabio Luciani
Jul 7, 2020·Frontiers in Cell and Developmental Biology·Tiago Cardoso, Martin Lévesque
Oct 8, 2020·Bioinformatics·Pierre-Cyril Aubin-Frankowski, Jean-Philippe Vert
Oct 22, 2020·NPJ Genomic Medicine·Andrew E Teschendorff, Ning Wang
Dec 8, 2020·Briefings in Bioinformatics·Edwin VansAlok Sharma
Dec 15, 2020·Briefings in Bioinformatics·Zilong ZhangQuan Zou
Dec 18, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Christoph KuppeRafael Kramann
Nov 28, 2020·Bioinformatics·Andrew E TeschendorffMatthias Lechner
Mar 5, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Gregory M ChenKai Tan
Apr 5, 2017·Cancer Research·Avrum SpiraScott M Lippman
Mar 5, 2016·Cancer Research·Xiaoyan ZhangShixiu Wu
Jun 10, 2017·Molecular Cancer Research : MCR·Ravi G Gupta, Robert A Somer
Jul 31, 2020·Computational and Structural Biotechnology Journal·Michal T SewerynQin Ma
Oct 27, 2020·Computational and Structural Biotechnology Journal·Justin D SilvermanLawrence A David
Nov 20, 2020·Computational and Structural Biotechnology Journal·Yaru ZhangJianzhong Su
Oct 10, 2020·Computational and Structural Biotechnology Journal·Nuosi WuWeixin Xie
Jan 14, 2021·Interdisciplinary Sciences, Computational Life Sciences·Jiang XieJiao Wang
Jan 17, 2021·Nature Protocols·Elisabet Rosàs-CanyellesAmy E Herr
Sep 2, 2020·Cell Systems·Payam Dibaeinia, Saurabh Sinha
Feb 2, 2021·Emerging Topics in Life Sciences·Sai Guna Ranjan GurazadaBlake C Meyers
Nov 17, 2020·Frontiers in Cell and Developmental Biology·Yanglan GanGuobing Zou
Feb 16, 2021·American Journal of Physiology. Endocrinology and Metabolism·Mario A MirandaHeather A Lawson
Feb 13, 2021·International Journal of Molecular Sciences·Salim GhannoumAlvaro Köhn-Luque
Dec 4, 2020·Journal for Immunotherapy of Cancer·Siwen Hu-LieskovanHolden T Maecker
Feb 17, 2021·Nature Communications·Duc TranTin Nguyen
Jan 20, 2021·ACS Biomaterials Science & Engineering·Vittorio FerraraBruno Pignataro

Related Concepts

Metazoa
Cell Differentiation Process
Poly(A) Tail
Computer Programs and Programming
MRNA Differential Display
Gene Modules
Single-Cell Analysis
High-Throughput Nucleotide Sequencing
Gene Expression Profiles
Gene Expression

Related Feeds

CZI Human Cell Atlas Seed Network

The aim of the Human Cell Atlas (HCA) is to build reference maps of all human cells in order to enhance our understanding of health and disease. The Seed Networks for the HCA project aims to bring together collaborators with different areas of expertise in order to facilitate the development of the HCA. Find the latest research from members of the HCA Seed Networks here.