PMID: 11604075Oct 18, 2001Paper

Computational approach for determining the spectrum of DNA damage induced by ionizing radiation

Radiation Research
H NikjooD T Goodhead

Abstract

To study the characteristics of molecular damage induced by ionizing radiation at the DNA level, Monte Carlo track simulation of energetic electrons and ions in liquid water, a canonical model of B-DNA, and a comprehensive classification of DNA damage in terms of the origin and complexity of damage were used to calculate the frequencies of simple and complex strand breaks. A threshold energy of 17.5 eV was used to model the damage by direct energy deposition, and a probability of 0.13 was applied to model the induction of a single-strand break produced in DNA by OH radical reactions. For preliminary estimates, base damage was assumed to be induced by the same direct energy threshold deposition or by the reaction of an OH radical with the base, with a probability of 0.8. Computational data are given on the complexity of damage, including base damage by electrons with energies of 100-4500 eV and ions with energies of 0.3-4.0 MeV/nucleon (59-9 keV microm(-1) protons and 170-55 keV microm(-1) alpha particles). Computational data are presented on the frequencies of single- and double-strand breaks induced as a function of the LET of the particles, and on the relative frequencies of complex single- and double-strand breaks for electr...Continue Reading

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Citations

Feb 19, 2013·Future Oncology·David R Raleigh, Daphne A Haas-Kogan
Jan 21, 2014·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Reza Taleei, Hooshang Nikjoo
Aug 24, 2011·Medical Physics·M A BernalP Nieminen
Sep 14, 2010·Medical Physics·Adriana Alexandre S Tavares, João Manuel R S Tavares
Jul 19, 2005·Proceedings of the National Academy of Sciences of the United States of America·Kamal DattaThomas A Winters
Jan 1, 2012·ISRN Molecular Biology·Lawrence F Povirk
Nov 18, 2014·Nature Communications·Shailja PathaniaDavid M Livingston
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Jan 14, 2005·Nucleic Acids Research·Grégory Eot-HoullierEvelyne Sage
May 1, 2007·Nucleic Acids Research·Grégory Eot-HoullierEvelyne Sage
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Nov 30, 2010·Radiation Protection Dosimetry·K M Prise, G Schettino
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Mar 5, 2004·Expert Opinion on Biological Therapy·Maria G Russeva, Gregory P Adams

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