Computational approaches for pharmacovigilance signal detection: toward integrated and semantically-enriched frameworks

Drug Safety : an International Journal of Medical Toxicology and Drug Experience
V G Koutkias, Marie-Christine Jaulent

Abstract

Computational signal detection constitutes a key element of postmarketing drug monitoring and surveillance. Diverse data sources are considered within the 'search space' of pharmacovigilance scientists, and respective data analysis methods are employed, all with their qualities and shortcomings, towards more timely and accurate signal detection. Recent systematic comparative studies highlighted not only event-based and data-source-based differential performance across methods but also their complementarity. These findings reinforce the arguments for exploiting all possible information sources for drug safety and the parallel use of multiple signal detection methods. Combinatorial signal detection has been pursued in few studies up to now, employing a rather limited number of methods and data sources but illustrating well-promising outcomes. However, the large-scale realization of this approach requires systematic frameworks to address the challenges of the concurrent analysis setting. In this paper, we argue that semantic technologies provide the means to address some of these challenges, and we particularly highlight their contribution in (a) annotating data sources and analysis methods with quality attributes to facilitate th...Continue Reading

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Citations

Nov 23, 2015·Journal of Medical Systems·Vassilis Koutkias, Marie-Christine Jaulent
Sep 2, 2015·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·John D Seeger
Jun 25, 2016·Genome Medicine·Charles AuffrayGianluigi Zanetti
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Nov 5, 2016·Expert Opinion on Drug Safety·Vassilis G KoutkiasMarie-Christine Jaulent
Jan 17, 2019·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Suehyun LeeJu Han Kim
Jan 23, 2019·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Vassilis Koutkias
Jul 29, 2020·Therapeutic Innovation & Regulatory Science·Inyoung LeeTodd A Lee
Mar 9, 2017·Journal of Biomedical Semantics·UNKNOWN Knowledge Base workgroup of the Observational Health Data Sciences and Informatics (OHDSI) collaborative
Jan 11, 2020·Frontiers in Pharmacology·Francesco De PretisBarbara Osimani
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Jun 4, 2019·Frontiers in Pharmacology·Pantelis NatsiavasVassilis Koutkias
Jun 27, 2019·International Journal of Environmental Research and Public Health·Francesco De Pretis, Barbara Osimani

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Software Mentioned

MedDRA
PROMPT
OntoADR
PharmaMiner
OMOP
BioPortal
openFDA
SALUS

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