Computational characterization and identification of human polycystic ovary syndrome genes

Scientific Reports
Xing-Zhong ZhangYan-Hui Li

Abstract

Human polycystic ovary syndrome (PCOS) is a highly heritable disease regulated by genetic and environmental factors. Identifying PCOS genes is time consuming and costly in wet-lab. Developing an algorithm to predict PCOS candidates will be helpful. In this study, for the first time, we systematically analyzed properties of human PCOS genes. Compared with genes not yet known to be involved in PCOS regulation, known PCOS genes display distinguishing characteristics: (i) they tend to be located at network center; (ii) they tend to interact with each other; (iii) they tend to enrich in certain biological processes. Based on these features, we developed a machine-learning algorithm to predict new PCOS genes. 233 PCOS candidates were predicted with a posterior probability >0.9. Evidence supporting 7 of the top 10 predictions has been found.

References

Feb 13, 2001·Fertility and Sterility·M D Kahsar-MillerR Azziz
May 3, 2001·Nature·H JeongZ N Oltvai
Jun 8, 2004·Nucleic Acids Research·Núria López-Bigas, Christos A Ouzounis
Aug 17, 2004·Molecular Endocrinology·Erik JansenBart C J M Fauser
Jan 4, 2005·Proteomics·Stefan Wuchty, Eivind Almaas
Jan 20, 2005·Bioinformatics·Kevin R Brown, Igor Jurisica
Aug 11, 2005·The Journal of Clinical Endocrinology and Metabolism·M UrbanekR S Spielman
Oct 13, 2005·The Journal of Clinical Endocrinology and Metabolism·J M VinkD I Boomsma
Jan 13, 2006·BMC Genomics·Simon J FurneyNúria López-Bigas
Apr 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·Susan SamAndrea Dunaif
Jul 28, 2006·BMC Genomics·Chad L MyersOlga G Troyanskaya
Oct 26, 2006·The Journal of Clinical Endocrinology and Metabolism·Marta CortónBelén Peral
Feb 7, 2008·IEEE Transactions on Neural Networks·J Y Kwok
May 24, 2008·Human Reproduction Update·Stephen FranksKate Hardy
Sep 29, 2009·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Kemal OzerkanMehpare Tüfekçi
Jun 10, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Gang Zhong, Biheng Chen
Oct 12, 2010·Mechanisms of Ageing and Development·Yan-Hui LiZheng Guo
Apr 10, 2014·Seminars in Reproductive Medicine·Corrine K Welt, Jessica M Duran
Jan 6, 2016·Nature Reviews. Endocrinology·Ricardo Azziz
May 3, 2016·American Journal of Human Genetics·Hamdi MbarekDorret I Boomsma
May 18, 2016·Fertility and Sterility·Michelle R Jones, Mark O Goodarzi
May 24, 2016·Bioinformation·Maniraja Jesintha MaryVijayalakshmi Melanathuru
Jun 25, 2016·Systems Biology in Reproductive Medicine·Medi KoriKazim Yalcin Arga
Jul 15, 2016·The New England Journal of Medicine·Christopher R McCartney, John C Marshall
Aug 12, 2016·Seminars in Reproductive Medicine·Hongbin LiuZi-Jiang Chen
Nov 30, 2016·Hypertension·Yan-Hui LiNanping Wang
Apr 14, 2017·Journal of Gynecology Obstetrics and Human Reproduction·X-Q WuJ-P Zhang

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Software Mentioned

MATLAB
LIBSVM
LIBSVM3
mathrm

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