Computational comparison of microtubule-stabilising agents laulimalide and peloruside with taxol and colchicine

Bioorganic & Medicinal Chemistry Letters
Oriol PinedaJaume Vilarrasa

Abstract

Microtubule-stabilising agents laulimalide and peloruside have been compared with tubulin-interacting drugs paclitaxel and colchicine by different computational approaches. Docking and QSAR-based programs point to a favourable interaction with the beta tubulin paclitaxel binding site, although an additional, preferred binding site has been found at the alpha subunit of tubulin. All together provides a plausible rationalisation of the singular binding features of these microtubule stabilisers and paves the way for future structural studies.

Citations

Feb 20, 2010·Investigational New Drugs·Ariane ChanJohn H Miller
Jun 27, 2012·Pharmaceutical Research·Melissa M GajewskiJack A Tuszynski
Mar 29, 2007·Natural Product Reports·Karl-Heinz Altmann, Jürg Gertsch
Sep 21, 2007·Molecular Biology of the Cell·Christopher MaNaomi S Morrissette
Feb 8, 2006·FEBS Letters·Csaba Hetényi, David van der Spoel
Dec 27, 2015·Pharmacology & Therapeutics·Ying ZhaoGuanhua Du
Oct 26, 2010·Fitoterapia·Inamullah KhanSyed Muhammad Abdullah
Apr 15, 2008·Journal of Molecular Biology·J Torin HuzilDavid C Schriemer
Oct 26, 2013·Journal of Enzyme Inhibition and Medicinal Chemistry·Si-Yan LiaoKang-Cheng Zheng
Dec 10, 2013·Expert Opinion on Therapeutic Patents·Yi-Min LiuJing-Ping Liou
Mar 26, 2013·Chemistry & Biology·Jessica J FieldJohn H Miller
Jul 23, 2013·Journal of Molecular Graphics & Modelling·Ahmed T AyoubJack Tuszynski
Mar 13, 2014·Journal of Biomolecular Structure & Dynamics·N FaniS Sepehri
May 18, 2016·Expert Opinion on Investigational Drugs·Kunal NepaliJing-Ping Liou
Jan 21, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alejandro Castro-AlvarezJaume Vilarrasa
Jul 29, 2010·Chembiochem : a European Journal of Chemical Biology·Benet PeraJosé Fernando Díaz
May 16, 2009·Expert Opinion on Therapeutic Patents·Ying ZhaoKlaus Pors
Mar 5, 2011·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Bijan Kumar Paul, Nikhil Guchhait
Feb 20, 2017·Journal of Molecular Modeling·Fabian E OlazaránGildardo Rivera
May 16, 2007·The Journal of Organic Chemistry·Masashi TsudaKenji Omasa
Feb 10, 2010·Organic Letters·Christoph W WullschlegerKarl-Heinz Altmann
Apr 2, 2009·Molecular Pharmaceutics·Corwin Hansch, Rajeshwar P Verma
Jul 6, 2006·Journal of the American Chemical Society·Jesús Jiménez-BarberoJ Fernando Díaz
Dec 8, 2009·Carbohydrate Research·Abolfazl BarzegarSaman Hosseini Ashtiani

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.