Computational design of treatment strategies for proactive therapy on atopic dermatitis using optimal control theory

Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
Panayiotis ChristodoulidesReiko J Tanaka

Abstract

Atopic dermatitis (AD) is a common chronic skin disease characterized by recurrent skin inflammation and a weak skin barrier, and is known to be a precursor to other allergic diseases such as asthma. AD affects up to 25% of children worldwide and the incidence continues to rise. There is still uncertainty about the optimal treatment strategy in terms of choice of treatment, potency, duration and frequency. This study aims to develop a computational method to design optimal treatment strategies for the clinically recommended 'proactive therapy' for AD. Proactive therapy aims to prevent recurrent flares once the disease has been brought under initial control. Typically, this is done by using an anti-inflammatory treatment such as a potent topical corticosteroid intensively for a few weeks to 'get control', followed by intermittent weekly treatment to suppress subclinical inflammation to 'keep control'. Using a hybrid mathematical model of AD pathogenesis that we recently proposed, we computationally derived the optimal treatment strategies for individual virtual patient cohorts, by recursively solving optimal control problems using a differential evolution algorithm. Our simulation results suggest that such an approach can inform...Continue Reading

References

Jun 3, 2005·The New England Journal of Medicine·Hywel C Williams
Jun 13, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Daniela RozkovaRadek Spisek
Jul 4, 2006·The Journal of Allergy and Clinical Immunology·Torsten ZuberbierJan C Simon
May 5, 2009·The Journal of Allergy and Clinical Immunology·Jens-Michael JensenEhrhardt Proksch
Jun 6, 2009·The Journal of Investigative Dermatology·Michael J CorkSimon J Ward
Jan 15, 2010·Current Medical Research and Opinion·Eric L Simpson
May 28, 2011·Pediatric Dermatology·Rachel M EllisJudith V Williams
Jun 16, 2011·The British Journal of Dermatology·H Aubert-WastiauxS Barbarot
Jul 21, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·J RingUNKNOWN Global Allergy and Asthma European Network
Aug 11, 2012·Annals of Dermatology·Andreas Wollenberg, Laura Maximiliane Ehmann
Mar 25, 2014·The Journal of Allergy and Clinical Immunology·Ting Seng TangHywel C Williams
Apr 1, 2014·Methods : a Companion to Methods in Enzymology·Yoshito HirataKazuyuki Aihara
May 13, 2014·Journal of the American Academy of Dermatology·Lawrence F EichenfieldRobert Sidbury
Aug 6, 2014·IEEE Transactions on Cybernetics·Ming YangJing Guan
Oct 14, 2014·PloS One·Devaraj JayachandranDoraiswami Ramkrishna
Sep 18, 2015·Lancet·Stephan Weidinger, Natalija Novak
Dec 10, 2016·The Journal of Allergy and Clinical Immunology·Elisa Domínguez-HüttingerReiko J Tanaka

❮ Previous
Next ❯

Citations

Aug 5, 2020·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Guillem HuraultReiko J Tanaka
May 17, 2017·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·José M Amigó, Michael Small
Dec 8, 2018··Reiko J. TanakalMark D.A. van Logtestijn

❮ Previous
Next ❯

Software Mentioned

DE
Matlab

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

The British Journal of Dermatology
C Gelmetti, Andreas Wollenberg
Annals of Dermatology
Andreas Wollenberg, Laura Maximiliane Ehmann
Journal of Investigational Allergology & Clinical Immunology
A Sala-CunillSkin Allergy Committee of Spanish Society of Allergy and Clinical Immunology (SEAIC)
Current Medical Research and Opinion
Eric L Simpson
© 2022 Meta ULC. All rights reserved