Computational evaluation of amplitude modulation for enhanced magnetic nanoparticle hyperthermia

Biomedizinische Technik. Biomedical Engineering
Frederik SoetaertGuillaume Crevecoeur

Abstract

Magnetic nanoparticles (MNPs) can interact with alternating magnetic fields (AMFs) to deposit localized energy for hyperthermia treatment of cancer. Hyperthermia is useful in the context of multimodality treatments with radiation or chemotherapy to enhance disease control without increased toxicity. The unique attributes of heat deposition and transfer with MNPs have generated considerable attention and have been the focus of extensive investigations to elucidate mechanisms and optimize performance. Three-dimensional (3D) simulations are often conducted with the finite element method (FEM) using the Pennes' bioheat equation. In the current study, the Pennes' equation was modified to include a thermal damage-dependent perfusion profile to improve model predictions with respect to known physiological responses to tissue heating. A normal distribution of MNPs in a model liver tumor was combined with empirical nanoparticle heating data to calculate tumor temperature distributions and resulting survival fraction of cancer cells. In addition, calculated spatiotemporal temperature changes were compared among magnetic field amplitude modulations of a base 150-kHz sinusoidal waveform, specifically, no modulation, sinusoidal, rectangular...Continue Reading

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Citations

Oct 2, 2015·Biomedizinische Technik. Biomedical Engineering·Lutz Trahms
Apr 1, 2017·IEEE Transactions on Bio-medical Engineering·John A PearceP Jack Hoopes
Dec 14, 2018·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Sri Kamal KandalaRobert Ivkov
Jan 11, 2020·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Anilchandra AttaluriRobert Ivkov
Jan 12, 2021·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Anilchandra AttaluriRobert Ivkov
Jan 12, 2021·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Chun-Ting YangRobert Ivkov
Apr 16, 2021·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Sri Kamal KandalaAnilchandra Attaluri

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Software Mentioned

ONELAB
GetDP
1DFEM
Gmsh
eqalign
MATLAB

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