Computational Feasibility Analysis of Electrochemotherapy With Novel Needle-Electrode Arrays for the Treatment of Invasive Breast Ductal Carcinoma

Technology in Cancer Research & Treatment
Adriana Leticia Vera-TizatlBor Kos

Abstract

Breast cancer represents a rising problem concerning public health worldwide. Current efforts are aimed to the development of new minimally invasive and conservative treatment procedures for this disease. A treatment approach for invasive breast ductal carcinoma could be based on electroporation. Hence, in order to determine the effectiveness of electrochemotherapy in the treatment of this disease, 12 electrode models were investigated on realistic patient-specific computational breast models of 3 patients diagnosed by Digital Breast Tomosynthesis imaging. The electrode models exhibit 4, 5, and 6 needles arranged in 4 geometric configurations (delta, diamond, and star) and 3 different needle spacing resulting in a total of 12 needle-electrode arrays. Electric field distribution in the tumors and a surrounding safety margin of 1 cm around the tumor edge is computed using the finite element method. Efficiency of the electrode arrays was determined hierarchically based on (1) percentage of tumor volume reversibly electroporated, (2) percentage of tumor volume irreversibly electroporated, (3) percentage of treated safety margin volume, (4) minimal invasiveness, that is, minimal number of electrodes used, (5) minimal activated elect...Continue Reading

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Citations

Jan 4, 2020·International Journal for Numerical Methods in Biomedical Engineering·Fabián M Vélez SalazarCarlos A Ruiz Villa
Aug 9, 2020·Electromagnetic Biology and Medicine·C E Vera-TizatlA L Vera-Tizatl
Sep 23, 2020·Artificial Organs·Maurício Martins TaquesDaniela Ota Hisayasu Suzuki
Dec 1, 2019·Bioelectricity·Maja Cemazar, Gregor Sersa

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Methods Mentioned

BETA
X-ray
surgical resection

Software Mentioned

Matlab
Slicer
COMSOL Multiphysics

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