Computational fluid dynamics applied to virtually deployed drug-eluting coronary bioresorbable scaffolds: Clinical translations derived from a proof-of-concept

Global Cardiology Science & Practice
Bill D GogasHabib Samady

Abstract

Three-dimensional design simulations of coronary metallic stents utilizing mathematical and computational algorithms have emerged as important tools for understanding biomechanical stent properties, predicting the interaction of the implanted platform with the adjacent tissue, and informing stent design enhancements. Herein, we demonstrate the hemodynamic implications following virtual implantation of bioresorbable scaffolds using finite element methods and advanced computational fluid dynamics (CFD) simulations to visualize the device-flow interaction immediately after implantation and following scaffold resorption over time. CFD simulations with time averaged wall shear stress (WSS) quantification following virtual bioresorbable scaffold deployment in idealized straight and curved geometries were performed. WSS was calculated at the inflow, endoluminal surface (top surface of the strut), and outflow of each strut surface post-procedure (stage I) and at a time point when 33% of scaffold resorption has occurred (stage II). The average WSS at stage I over the inflow and outflow surfaces was 3.2 and 3.1 dynes/cm(2) respectively and 87.5 dynes/cm(2) over endoluminal strut surface in the straight vessel. From stage I to stage II, W...Continue Reading

References

Nov 1, 1993·Journal of Biomechanical Engineering·R M Nerem
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Nov 23, 2010·JACC. Cardiovascular Interventions·Josep Gomez-LaraPatrick W Serruys
Jul 23, 2011·JACC. Cardiovascular Interventions·Michael C McDaniel, Habib Samady
Dec 15, 2009·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Joanna J WykrzykowskaPatrick W Serruys
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Apr 18, 2013·Cardiovascular Research·Kim Van der HeidenPaul C Evans
Jul 20, 2013·JACC. Cardiovascular Interventions·Bill D GogasHabib Samady

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Citations

Jan 1, 2014·Global Cardiology Science & Practice·Bill D Gogas
May 2, 2017·Frontiers in Physiology·Francesca DonadoniVanessa Díaz-Zuccarini

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Methods Mentioned

BETA
imaging techniques

Software Mentioned

SPSS
Netgen
Rhino

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