Aug 23, 2016

Computational fluid dynamics modelling of left valvular heart diseases during atrial fibrillation

PeerJ
S ScarsoglioMatteo Anselmino

Abstract

Although atrial fibrillation (AF), a common arrhythmia, frequently presents in patients with underlying valvular disease, its hemodynamic contributions are not fully understood. The present work aimed to computationally study how physical conditions imposed by pathologic valvular anatomy act on AF hemodynamics. We simulated AF with different severity grades of left-sided valvular diseases and compared the cardiovascular effects that they exert during AF, compared to lone AF. The fluid dynamics model used here has been recently validated for lone AF and relies on a lumped parameterization of the four heart chambers, together with the systemic and pulmonary circulation. The AF modelling involves: (i) irregular, uncorrelated and faster heart rate; (ii) atrial contractility dysfunction. Three different grades of severity (mild, moderate, severe) were analyzed for each of the four valvulopathies (AS, aortic stenosis, MS, mitral stenosis, AR, aortic regurgitation, MR, mitral regurgitation), by varying-through the valve opening angle-the valve area. Regurgitation was hemodynamically more relevant than stenosis, as the latter led to inefficient cardiac flow, while the former introduced more drastic fluid dynamics variation. Moreover, m...Continue Reading

Mentioned in this Paper

Study
Rheumatic Mitral Stenosis
Exertion
Magnetic Resonance Imaging
Lung
Mitral Valve
Mitral Valve Stenosis
Cardiac Chamber Structure
Aortic Valve Disorder
Atrial Septal Defects

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