Jun 2, 2020

Computational Hemodynamic Modeling of Arterial Aneurysms: A Mini-Review

Frontiers in Physiology
Sarah N LippCraig J Goergen

Abstract

Arterial aneurysms are pathological dilations of blood vessels, which can be of clinical concern due to thrombosis, dissection, or rupture. Aneurysms can form throughout the arterial system, including intracranial, thoracic, abdominal, visceral, peripheral, or coronary arteries. Currently, aneurysm diameter and expansion rates are the most commonly used metrics to assess rupture risk. Surgical or endovascular interventions are clinical treatment options, but are invasive and associated with risk for the patient. For aneurysms in locations where thrombosis is the primary concern, diameter is also used to determine the level of therapeutic anticoagulation, a treatment that increases the possibility of internal bleeding. Since simple diameter is often insufficient to reliably determine rupture and thrombosis risk, computational hemodynamic simulations are being developed to help assess when an intervention is warranted. Created from subject-specific data, computational models have the potential to be used to predict growth, dissection, rupture, and thrombus-formation risk based on hemodynamic parameters, including wall shear stress, oscillatory shear index, residence time, and anomalous blood flow patterns. Generally, endothelial ...Continue Reading

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Mentioned in this Paper

Peripheral
Stratification
Intracranial
Aneurysm
Extracellular Matrix
Aneurysm of Hepatic Artery
Blood Vessel
Internal; Hemorrhage
Tissue Dissection
Endothelium

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