Computational high-resolution optical imaging of the living human retina

Nature Photonics
Nathan D ShemonskiStephen A Boppart

Abstract

High-resolution in vivo imaging is of great importance for the fields of biology and medicine. The introduction of hardware-based adaptive optics (HAO) has pushed the limits of optical imaging, enabling high-resolution near diffraction-limited imaging of previously unresolvable structures(1,2). In ophthalmology, when combined with optical coherence tomography, HAO has enabled a detailed three-dimensional visualization of photoreceptor distributions(3,4) and individual nerve fibre bundles(5) in the living human retina. However, the introduction of HAO hardware and supporting software adds considerable complexity and cost to an imaging system, limiting the number of researchers and medical professionals who could benefit from the technology. Here we demonstrate a fully automated computational approach that enables high-resolution in vivo ophthalmic imaging without the need for HAO. The results demonstrate that computational methods in coherent microscopy are applicable in highly dynamic living systems.

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Citations

Nov 1, 2016·IEEE Journal of Selected Topics in Quantum Electronics : a Publication of the IEEE Lasers and Electro-optics Society·Fredrick A SouthStephen A Boppart
Dec 10, 2015·Applied Physics Letters·Fredrick A SouthStephen A Boppart
Oct 21, 2016·Photoacoustics·Wenzhong Liu, Hao F Zhang
Oct 30, 2016·Proceedings of the National Academy of Sciences of the United States of America·Dierck HillmannGereon Hüttmann
Feb 19, 2017·Vision Research·Susana MarcosLawrence C Sincich
Oct 21, 2016·Scientific Reports·Dierck HillmannGereon Hüttmann
Mar 9, 2017·Biomedical Optics Express·Olivier ThouveninA Claude Boccara
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May 23, 2017·Journal of Biomedical Optics·Dino Carpentras, Christophe Moser
Dec 21, 2017·Journal of Biomedical Optics·Guillermo L MonroyStephen A Boppart
Oct 19, 2017·Optics Express·Zhigang JiaFengzhou Fang
Jul 1, 2017·Biomedical Optics Express·Yuan-Zhi LiuStephen A Boppart
Sep 28, 2018·Biomedical Optics Express·Fredrick A SouthStephen A Boppart
Mar 2, 2019·Optics Letters·Fredrick A SouthStephen A Boppart
May 21, 2019·NMR in Biomedicine·Sean Philip ArlauckasEdward James Delikatny
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Mar 10, 2018·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Fredrick A SouthStephen A Boppart
Mar 20, 2018·Biomedical Optics Express·Laurin GinnerRainer A Leitgeb

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