Computational hyperspectral interferometry for studies of brain function: proof of concept

Applied Optics
Douglas J FoxT A Woolsey

Abstract

Hyperspectral interferometric microscopy uses a unique combination of optics and algorithm design to extract information. Local brain activity rapidly changes local blood flow and red blood cell concentration (absorption) and oxygenation (color). We demonstrate that brain activity evoked during whisker stimulation can be detected with hyperspectral interferometric microscopy to identify the active whisker-barrel cortex in the rat brain. Information about constituent components is extracted across the entire spectral band. Algorithms can be flexibly optimized to discover, detect, quantify, and visualize a wide range of significant biological events, including changes relevant to the diagnosis and treatment of disease.

References

Jan 1, 1992·Experimental Brain Research·D J SimonsD P Bryant
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S OgawaD W Tank
Dec 15, 1974·The Journal of Comparative Neurology·C Welker, T A Woolsey
Nov 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S B CoxC M Rovainen
Jun 1, 1996·Journal of Neuroscience Methods·J L DowlingT A Woolsey
Dec 3, 1999·International Journal of Dermatology·P Asawanonda, C R Taylor
Jan 22, 2000·Brain Research Bulletin·S S Kety
Mar 14, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Joseph P Erinjeri, Thomas A Woolsey
May 15, 2003·Trends in Neurosciences·Nader PouratianArthur W Toga
Aug 10, 2004·Current Opinion in Urology·Fadi N Joudi, Badrinath R Konety

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