Computational Intelligence Technique for Prediction of Multiple Sclerosis Based on Serum Cytokines

Frontiers in Neurology
Mehendi GoyalManoj Baranwal

Abstract

Multiple sclerosis (MS) is a neurodegenerative disease characterized by lesions in the central nervous system (CNS). Inflammation and demyelination are the leading causes of neuronal death and brain lesions formation. The immune reactivity is believed to be essential in the neuronal damage in MS. Cytokines play important role in differentiation of Th cells and recruitment of auto-reactive B and T lymphocytes that leads to neuron demyelination and death. Several cytokines have been found to be linked with MS pathogenesis. In the present study, serum level of eight cytokines (IL-1β, IL-2, IL-4, IL-8, IL-10, IL-13, IFN-γ, and TNF-α) was analyzed in USA and Russian MS to identify predictors for the disease. Further, the model was extended to classify MS into remitting and non-remitting by including age, gender, disease duration, Expanded Disability Status Scale (EDSS) and Multiple Sclerosis Severity Score (MSSS) into the cytokines datasets in Russian cohorts. The individual serum cytokines data for the USA cohort was generated by Z score percentile method using R studio, while serum cytokines of the Russian cohort were analyzed using multiplex immunoassay. Datasets were divided into training (70%) and testing (30%). These datasets ...Continue Reading

References

Apr 29, 1998·Immunology and Cell Biology·S R Ruuls, J D Sedgwick
Mar 3, 2006·The New England Journal of Medicine·Elliot M FrohmanCedric S Raine
Mar 24, 2009·Journal of Magnetic Resonance Imaging : JMRI·M M VellingaH Vrenken
May 16, 2009·Nature Reviews. Immunology·Joan Goverman
May 6, 2010·Current Opinion in Neurology·Laura CodarriBurkhard Becher
Dec 4, 2012·International Journal of Molecular Sciences·Amedeo AmedeiMario Milco D'Elios
Aug 2, 2014·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Anthony T Reder, Xuan Feng
Aug 8, 2015·Nature Reviews. Immunology·Calliope A DendrouManuel A Friese
Aug 22, 2015·BioMed Research International·Svetlana F KhaiboullinaAlbert A Rizvanov
Jan 1, 2016·Revue neurologique·E LerayG Edan
Jul 12, 2016·Journal of Neuroimmunology·Cather M CalaTara M DeSilva
Aug 20, 2016·Neurology. Genetics·Orhun H Kantarci
Dec 6, 2016·Nature Reviews. Immunology·Burkhard BecherJoan Goverman
Feb 20, 2017·Immunology Letters·Divya Khanna, Prashant Singh Rana
May 13, 2017·Journal of Diabetes Science and Technology·Arianna DagliatiRiccardo Bellazzi
May 26, 2017·PloS One·Seong Jae KimSejong Oh
Jun 3, 2017·Frontiers in Immunology·Timur KhaibullinSvetlana Khaiboullina
Mar 8, 2018·Multiple Sclerosis : Clinical and Laboratory Research·Kerstin GöbelSven G Meuth

❮ Previous
Next ❯

Citations

Nov 10, 2020·Mediators of Inflammation·Ekaterina MartynovaManoj Baranwal
Feb 8, 2021·Neurología : publicación oficial de la Sociedad Española de Neurología·M Vázquez-MarrufoG Izquierdo
Mar 28, 2021·Computers in Biology and Medicine·Morghan HartmannRuth Dobson
May 21, 2021·Frontiers in Immunology·Isabel VoigtTjalf Ziemssen

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies

Software Mentioned

MasterPlex CT
MasterPlex QT
R

Related Concepts

Related Feeds