PMID: 8944766Nov 1, 1996Paper

Computational method to predict mitochondrially imported proteins and their targeting sequences

European Journal of Biochemistry
M G Claros, P Vincens

Abstract

Most of the proteins that are used in mitochondria are imported through the double membrane of the organelle. The information that guides the protein to mitochondria is contained in its sequence and structure, although no direct evidence can be obtained. In this article, discriminant analysis has been performed with 47 parameters and a large set of mitochondrial proteins extracted from the SwissProt database. A computational method that facilitates the analysis and objective prediction of mitochondrially imported proteins has been developed. If only the amino acid sequence is considered, 75-97% of the mitochondrial proteins studied have been predicted to be imported into mitochondria. Moreover, the existence of mitochondrial-targeting sequences is predicted in 76-94% of the analyzed mitochondrial precursor proteins. As a practical application, the number of unknown yeast open reading frames that might be mitochondrial proteins has been predicted, which revealed that many of them are clustered.

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Citations

Nov 19, 2010·Cellular and Molecular Life Sciences : CMLS·Amrita RaiDietmar J Manstein
Sep 6, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Reetta HinttalaKari Majamaa
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Jun 15, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Shuo Cheng ZhangPaul R Murphy
May 23, 2012·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Zhi LiuGuangsheng Yang
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Jun 29, 2005·Journal of Molecular Evolution·Xuemei JiJohn Bennett
Jun 28, 2005·Journal of Molecular Evolution·Juli PeretóDavid Moreira
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Oct 26, 2010·Journal of Molecular Evolution·Heng XiangZhonghuai Xiang
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