Computational model-based assessment of baroreflex function from response to Valsalva maneuver

Journal of Applied Physiology
Samuel A KosinskiDaniel A Beard

Abstract

Functional metrics of autonomic control of heart rate, including baroreflex sensitivity, have been shown to be strongly associated with cardiovascular risk. A decrease in baroreflex sensitivity with aging is hypothesized to represent a contributing causal factor in the etiology of primary hypertension. To assess baroreflex function in human subjects, two complementary methods to simulate the response in heart rate elicited by the Valsalva maneuver were developed and applied to data obtained from a cohort of healthy normal volunteers. The first method is based on representing the baroreflex arc as a simple linear filter, transforming changes in arterial pressure to changes in R-R interval. The second method invokes a physiologically based model for arterial mechanics, afferent baroreceptor strain-dependent firing, and control of heart rate via central autonomic response to changes in afferent inputs from aortic and carotid sensors. Analysis based on the linear filter model reveals that the effective response time of the baroreflex arc tends to increase with age in healthy subjects and that the response time/response rate is a predictor of resting systolic pressure. Similar trends were obtained based on the physiologically based ...Continue Reading

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Citations

Nov 22, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jonathan Birjiniuk, Thomas Heldt
Aug 2, 2019·Journal of Applied Physiology·E Benjamin RandallMette S Olufsen
May 14, 2021·Journal of Theoretical Biology·E Benjamin RandallMette S Olufsen

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