Computational Model of Recurrent Subthalamo-Pallidal Circuit for Generation of Parkinsonian Oscillations

Frontiers in Neuroanatomy
Osamu ShounoKenji Doya

Abstract

Parkinson's disease is a movement disorder caused by dopamine depletion in the basal ganglia. Abnormally synchronized neuronal oscillations between 8 and 15 Hz in the basal ganglia are implicated in motor symptoms of Parkinson's disease. However, how these abnormal oscillations are generated and maintained in the dopamine-depleted state is unknown. Based on neural recordings in a primate model of Parkinson's disease and other experimental and computational evidence, we hypothesized that the recurrent circuit between the subthalamic nucleus (STN) and the external segment of the globus pallidus (GPe) generates and maintains parkinsonian oscillations, and that the cortical excitatory input to the STN amplifies them. To investigate this hypothesis through computer simulations, we developed a spiking neuron model of the STN-GPe circuit by incorporating electrophysiological properties of neurons and synapses. A systematic parameter search by computer simulation identified regions in the space of the intrinsic excitability of GPe neurons and synaptic strength from the GPe to the STN that reproduce normal and parkinsonian states. In the parkinsonian state, reduced firing of GPe neurons and increased GPe-STN inhibition trigger burst act...Continue Reading

References

Oct 1, 1989·Trends in Neurosciences·R L AlbinJ B Penney
Jul 19, 2000·Journal of Neurophysiology·A NambuN Hasegawa
May 23, 2002·Brain : a Journal of Neurology·Ron LevyJonathan O Dostrovsky
Sep 11, 2002·Trends in Neurosciences·Mark D BevanCharles J Wilson
Apr 3, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Peter Brown
Apr 29, 2004·Journal of Computational Neuroscience·Jonathan E Rubin, David Terman
Dec 17, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ramin AmirnovinEmad N Eskandar
Jul 21, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Peter Brown, David Williams
Sep 24, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hitoshi KitaSatomi Chiken
Jan 13, 2006·Journal of Neurophysiology·Michal Rivlin-EtzionIzhar Bar-Gad
Mar 16, 2006·The Journal of Comparative Neurology·Martin Parent, André Parent
Mar 31, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Arthur LebloisDavid Hansel
Jul 11, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Plamen GatevThomas Wichmann
Aug 4, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gali HeimerHagai Bergman
Jan 11, 2007·Archives of Neurology·Mahlon R DeLong, Thomas Wichmann
May 29, 2007·Trends in Neurosciences·Constance HammondPeter Brown
Jul 25, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Cengiz GünayDieter Jaeger
Jul 25, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Li LiangStella M Papa
Dec 26, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nicolas MalletPeter J Magill
May 22, 2009·Journal of Neurophysiology·Jérôme BaufretonMark D Bevan
Mar 24, 2010·Journal of Computational Neuroscience·Philip J Hahn, Cameron C McIntyre
Sep 17, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alejo J Nevado HolgadoRafal Bogacz
Nov 16, 2010·Nature Neuroscience·C Savio ChanD James Surmeier
Jul 29, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jeremy R Edgerton, Dieter Jaeger
Oct 27, 2011·Frontiers in Systems Neuroscience·Arvind KumarAd Aertsen
Nov 1, 2011·The European Journal of Neuroscience·Yoshihisa TachibanaAtsushi Nambu
Apr 28, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Takako Kita, Hitoshi Kita
May 2, 2012·The Journal of Physiology·B PollokM Südmeyer
Oct 5, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kai Y FanMark D Bevan
Apr 26, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jeremy F AthertonMark D Bevan
May 29, 2013·NeuroImage·John-Stuart Brittain, Peter Brown

❮ Previous
Next ❯

Citations

Mar 13, 2018·The European Journal of Neuroscience·Benjamin R Pittman-PollettaMichelle M McCarthy
Jun 12, 2018·International Journal of Neural Systems·Michael Caiola, Mark H Holmes
Mar 13, 2019·Frontiers in Neural Circuits·Vignayanandam Ravindernath MuddapuSrikanth Ramaswamy
Jan 24, 2018·Journal of Neurophysiology·Timothy O WestSimon F Farmer
Mar 29, 2020·Nature Communications·Brice de la CrompeNicolas P Mallet
Aug 21, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·C Warren OlanowJose A Obeso
Nov 13, 2019·Proceedings of the National Academy of Sciences of the United States of America·Jeremy W ChopekRobert M Brownstone
Apr 9, 2019·Cognitive Neurodynamics·Bing HuLiqing Zong
Jan 9, 2019·Frontiers in Physiology·Mojtaba Madadi AslPeter A Tass
Jan 20, 2020·Neuroscience Research·Yuichi Takeuchi, Antal Berényi

❮ Previous
Next ❯

Software Mentioned

statsmodels
Matplotlib
rpy2
R
Scipy
Numpy

Related Concepts

Related Feeds

Basal ganglia in Parkinson's disease (MDS)

The basal ganglia is comprised of the neostriatum, the external and internal pallidal segments, the subthalamic nucleus, the substantia nigra pars reticulata, and the pars compacta of the substantia nigra. The basal ganglia circuitry is responsible for the correct execution of voluntary movements and is implicated in Parkinson's disease. Here is the latest research investigating the basal ganglia in Parkinson's disease.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Related Papers

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Alejo J Nevado HolgadoRafal Bogacz
Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Guiyeom Kang, Madeleine M Lowery
© 2021 Meta ULC. All rights reserved