Computational Model To Quantify the Growth of Antibiotic-Resistant Bacteria in Wastewater.

MSystems
I. SutradharMuhammad H Zaman

Abstract

Although wastewater and sewage systems are known to be significant reservoirs of antibiotic-resistant bacterial populations and periodic outbreaks of drug-resistant infection, there is little quantitative understanding of the drivers behind resistant population growth in these settings. In order to fill this gap in quantitative understanding of the development of antibiotic-resistant infections in wastewater, we have developed a mathematical model synthesizing many known drivers of antibiotic resistance in these settings to help predict the growth of resistant populations in different environmental scenarios. A number of these drivers of drug-resistant infection outbreak, including antibiotic residue concentration, antibiotic interaction, chromosomal mutation, and horizontal gene transfer, have not previously been integrated into a single computational model. We validated the outputs of the model with quantitative studies conducted on the eVOLVER continuous culture platform. Our integrated model shows that low levels of antibiotic residues present in wastewater can lead to increased development of resistant populations and that the dominant mechanism of resistance acquisition in these populations is horizontal gene transfer rat...Continue Reading

References

Sep 1, 2004·Trends in Microbiology·P J HastingsAndrew Slack
Sep 26, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jean-Baptiste MichelRoy Kishony
Sep 17, 2013·Applied and Environmental Microbiology·Thomas K WoodBrian W Kwan
Jan 1, 2014·Applied and Environmental Microbiology·Karin E Kram, Steven E Finkel
May 28, 2014·Nature Reviews. Microbiology·Dan I Andersson, Diarmaid Hughes
Apr 11, 2015·Evolutionary Applications·Tom Vogwill, R Craig MacLean
Nov 23, 2015·Environment International·Johan Bengtsson-Palme, D G Joakim Larsson
Aug 31, 2016·Nature Microbiology·Allison J LopatkinLingchong You
Apr 2, 2017·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Yingying PuFan Bai
Nov 1, 2017·Frontiers in Microbiology·Jananee Jaishankar, Preeti Srivastava
Mar 30, 2018·Scientific Reports·Rafael D AcemelAlejandro Cuetos
Aug 29, 2018·Nature Communications·Zohar B WeinsteinMurat Cokol
Oct 6, 2018·Antimicrobial Resistance and Infection Control·Anna Camilla BirkegårdKaare Græsbøll
Mar 5, 2019·Evolutionary Applications·François Blanquart
Apr 25, 2019·BMC Medicine·Anna Maria NiewiadomskaCecile Viboud
Aug 23, 2019·Proceedings of the National Academy of Sciences of the United States of America·Nelson FrazãoIsabel Gordo
Oct 22, 2020·Antimicrobial Resistance and Infection Control·Philip BowlerRandall Wolcott
Oct 22, 2020·MSystems·Christian BrinchFrank M Aarestrup

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Software Mentioned

eVOLVER
MATLAB

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