Computational modeling and biomarker studies of pharmacological treatment of Alzheimer's disease (Review)

Molecular Medicine Reports
Mubashir HassanAhmed A Moustafa

Abstract

Alzheimer's disease (AD) is a complex and multifactorial disease. In order to understand the genetic influence in the progression of AD, and to identify novel pharmaceutical agents and their associated targets, the present study discusses computational modeling and biomarker evaluation approaches. Based on mechanistic signaling pathway approaches, various computational models, including biochemical and morphological models, are discussed to explore the strategies that may be used to target AD treatment. Different biomarkers are interpreted on the basis of morphological and functional features of amyloid β plaques and unstable microtubule‑associated tau protein, which is involved in neurodegeneration. Furthermore, imaging and cerebrospinal fluids are also considered to be key methods in the identification of novel markers for AD. In conclusion, the present study reviews various biochemical and morphological computational models and biomarkers to interpret novel targets and agonists for the treatment of AD. This review also highlights several therapeutic targets and their associated signaling pathways in AD, which may have potential to be used in the development of novel pharmacological agents for the treatment of patients with A...Continue Reading

References

May 1, 1992·Archives of Biochemistry and Biophysics·S J Tomski, R M Murphy
Aug 1, 1995·Current Opinion in Neurobiology·G Buzsáki, J J Chrobak
Mar 10, 1995·Science·J E Lisman, M A Idiart
Jan 1, 1995·The British Journal of Psychiatry : the Journal of Mental Science·E Ruppin, J A Reggia
Sep 1, 1994·Journal of Neuropathology and Experimental Neurology·D J Selkoe
Jul 1, 1993·British Medical Bulletin·P H Evans
Jul 1, 1993·Progress in Neurobiology·J MassouliéF M Vallette
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·W J StrittmatterA D Roses
May 28, 1993·Biochemical and Biophysical Research Communications·M RuatJ C Schwartz
Feb 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·A LomakinD B Teplow
Jan 1, 1996·Acta Neurologica Scandinavica. Supplementum·S Hoyer
May 1, 1996·Progress in Neuro-psychopharmacology & Biological Psychiatry·S XanthakosH C Charles
Dec 24, 1996·Proceedings of the National Academy of Sciences of the United States of America·T A Good, R M Murphy
Jul 8, 1997·Proceedings of the National Academy of Sciences of the United States of America·L CruzB T Hyman
Jul 22, 1997·Proceedings of the National Academy of Sciences of the United States of America·A LomakinG B Benedek
Aug 29, 1997·The Journal of Biological Chemistry·D M WalshD B Teplow
Jul 1, 1997·Neurobiology of Aging·H Braak, E Braak
Jul 8, 1998·Artificial Intelligence in Medicine·E D Menschik, L H Finkel
Mar 10, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·P T FrancisG K Wilcock
Mar 11, 1999·Annals of Neurology·J L Price, J C Morris
Jun 16, 1999·Archives of Neurology·V HaroutunianR C Mohs
Jan 19, 2000·Current Medicinal Chemistry·D L BaiX C He
Apr 12, 2000·Progress in Neurobiology·D Paterson, A Nordberg
Aug 15, 2000·Journal of Structural Biology·R M Murphy, M M Pallitto
Aug 15, 2000·Journal of Structural Biology·H Inouye, D A Kirschner
Jan 9, 2001·Journal of Neurochemistry·H F DoveyJ E Audia
May 3, 2002·Journal of Human Hypertension·F ContrerasM Velasco
Jul 12, 2002·Molecular Neurobiology·Jesús AvilaA Claudio Cuello
Aug 2, 2002·Neuroreport·Mitchell K P LaiChristopher P L-H Chen
Sep 6, 2002·Journal of Alzheimer's Disease : JAD·A Wevers, H Schröder

❮ Previous
Next ❯

Citations

Nov 7, 2019·Pharmaceutics·Francesca PederzoliAndreas M Grabrucker
Dec 14, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daniela Volpato, Ulrike Holzgrabe
Nov 17, 2020·Frontiers in Molecular Biosciences·Timothy E HoffmanJulie A Moreno

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.

Related Papers

Journal of the American Geriatrics Society
Donald R Royall
Frontiers in Bioscience : a Journal and Virtual Library
Gary E Gibson, Hsueh-Meei Huang
Clinical Biochemistry
Audrey Loumaye, Jean-Paul Thissen
The Journal of Medical Investigation : JMI
Christoph W TurckRichard Zollinger
© 2022 Meta ULC. All rights reserved