Computational Modeling of Antiviral Drug Diffusion from Poly(lactic- co-glycolic-acid) Fibers and Multicompartment Pharmacokinetics for Application to the Female Reproductive Tract

Molecular Pharmaceutics
Michael E HalwesHermann B Frieboes

Abstract

The need for more versatile technologies to deliver antiviral agents to the female reproductive tract (FRT) has spurred the development of on-demand and sustained-release platforms. Electrospun fibers (EFs), in particular, have recently been applied to FRT delivery, resulting in an alternative dosage form with the potential to provide protection and therapeutic effect against a variety of infection types. However, a multitude of fabrication parameters, as well as the resulting complexities of solvent-drug, drug-polymer, and solvent-polymer interactions, are known to significantly impact the loading and release of incorporated agents. Numerous processing parameters, in addition to their combined interactions, can hinder the iterative development of fiber formulations to achieve optimal release for particular durations, doses, and polymer-drug types. The experimental effort to design and develop EFs could benefit from mathematical analysis and computational simulation that predictively evaluate combinations of parameters to meet product design needs. Here, existing modeling efforts are leveraged to develop a simulation platform that correlates and predicts the delivery of relevant small molecule antivirals from EFs that have been...Continue Reading

References

Dec 31, 1997·The American Journal of Physiology·S KalyanasundaramK W Leong
Jun 11, 1999·Contraception·D H Owen, D F Katz
Oct 17, 2003·European Cells & Materials·P A Gunatillake, R Adhikari
Feb 19, 2008·Biomaterials·Travis J Sill, Horst A von Recum
Jan 13, 2009·Advanced Drug Delivery Reviews·Yen Cu, W Mark Saltzman
Mar 12, 2010·Journal of Pharmaceutical Sciences·Anthony R Geonnotti, David F Katz
Aug 17, 2011·Journal of Drug Delivery·Like ZengXiaoyi Wu
Jun 19, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jill M SteinbachW Mark Saltzman
Apr 26, 2013·Critical Reviews in Therapeutic Drug Carrier Systems·Daniel J Hines, David L Kaplan
Aug 3, 2013·Journal of Biomaterials Science. Polymer Edition·Ning HanJessica O Winter
Aug 31, 2013·International Journal of Nanomedicine·Edgar MarinCatherina Caballero-George
Nov 6, 2013·Antiviral Research·Anna K BlakneyKim A Woodrow
Jan 11, 2014·Clinical Investigation·Melanie R NicolAngela Dm Kashuba
Apr 29, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xiuli HuXiabin Jing
Jun 11, 2014·Antimicrobial Agents and Chemotherapy·Cameron Ball, Kim A Woodrow
Sep 18, 2014·Molecular Pharmaceutics·Tommaso CasaliniMaurizio Masi
Dec 17, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Melanie R NicolAngela D M Kashuba
Apr 7, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Shan ZongXiabin Jing
Apr 16, 2015·Drug Delivery and Translational Research·Y GaoD F Katz
Aug 24, 2016·Antimicrobial Agents and Chemotherapy·Tiffany N GroomsJill M Steinbach-Rankins
Sep 7, 2016·Journal of Pharmaceutical and Biomedical Analysis·Péter SzabóRomána Zelkó
Oct 19, 2016·Journal of the Mechanical Behavior of Biomedical Materials·Shih-Feng Chou, Kim A Woodrow
Dec 28, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Stella E AniagyeiJill M Steinbach-Rankins
Aug 12, 2017·International Journal of Pharmaceutics·Kevin M TyoJill M Steinbach-Rankins
Aug 15, 2017·Biomaterials·Emily A KrogstadKim A Woodrow

❮ Previous
Next ❯

Citations

Apr 14, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Hasham S SofiFaheem A Sheikh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.