Computational modeling of cancer cachexia.

Current Opinion in Clinical Nutrition and Metabolic Care
Kevin D Hall, Vickie E Baracos

Abstract

Measurements of whole-body energy expenditure, body composition, and in-vivo metabolic fluxes are required to quantitatively understand involuntary weight loss in cancer cachexia. Such studies are rare because cancer cachexia occurs near the end of life when invasive metabolic tests may be precluded. Thus, models of cancer-associated weight loss are an important tool for helping to understand this debilitating condition. A computational model of human macronutrient metabolism was recently developed that simulates the normal metabolic adaptations to semi-starvation and re-feeding. Here, this model was used to integrate data on the metabolic changes in patients with cancer cachexia. The resulting computer simulations show how the known metabolic disturbances synergize with reduced energy intake to result in a progressive loss of body weight, fat mass, and fat-free mass. The model was also used to simulate the effects of nutritional support and investigate inhibition of lipolysis versus proteolysis as potential therapeutic approaches for cancer cachexia. Computational modeling is a new tool that can integrate clinical data on the metabolic changes in cancer cachexia and provide a conceptual framework to help understand involuntary...Continue Reading

References

Nov 1, 1990·The Journal of Clinical Investigation·S Klein, R R Wolfe
Jun 15, 1989·Cancer·M J Wizenberg
Oct 1, 1987·Metabolism: Clinical and Experimental·A LegaspiM F Brennan
Mar 1, 1987·Metabolism: Clinical and Experimental·J MacFie, L Burkinshaw
Apr 1, 1986·Metabolism: Clinical and Experimental·M JeevanandamM F Brennan
Mar 19, 1970·The New England Journal of Medicine·G F Cahill
Nov 1, 1984·Metabolism: Clinical and Experimental·E EdénK Lundholm
Mar 1, 1993·Metabolism: Clinical and Experimental·E W RichardsW S Blakemore
Jul 17, 1998·The American Journal of Clinical Nutrition·O E OwenE K Dawson
Jul 28, 1999·Nutrition·P W Emery
Apr 25, 2000·World Journal of Surgery·M D BarberK C Fearon
Jun 1, 2000·Metabolism: Clinical and Experimental·K H PoldermanL J Gooren
Jul 26, 2000·Metabolism: Clinical and Experimental·S D Zuijdgeest-van LeeuwenP C Dagnelie
Jan 11, 2000·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M Elia
Dec 13, 2000·Surgical Oncology·M D BarberK C Fearon
Nov 5, 2002·Nature Reviews. Cancer·Michael J Tisdale
Nov 8, 2002·The Journal of Nutrition·Ingvar BosaeusKent Lundholm
Jun 12, 2004·Current Opinion in Clinical Nutrition and Metabolic Care·Eduardo J B RamosMichael M Meguid
Jun 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Aminah JatoiUNKNOWN North Central Cancer Treatment Group
Aug 25, 1950·Science·H L TAYLOR, A KEYS
Oct 21, 2004·European Journal of Clinical Nutrition·C KremsM Neuhäuser-Berthold
Jul 28, 2005·The Journal of Nutrition·Donald K LaymanRichard A Boileau
Feb 2, 2006·American Journal of Physiology. Endocrinology and Metabolism·Kevin D Hall
Jul 20, 2006·Annual Review of Nutrition·George F Cahill
Nov 10, 2006·The American Journal of Clinical Nutrition·Joanne L HuttonVickie E Baracos
Nov 23, 2006·Cytokine & Growth Factor Reviews·Amarjit SainiClaire E H Stewart
Jan 30, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·G C MajorA Tremblay
Mar 21, 2007·The British Journal of Nutrition·Kevin D Hall
May 18, 2007·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Richard J E SkipworthKenneth C H Fearon
Jun 5, 2007·Cancer Research·Thorhallur AgustssonPeter Arner
Dec 15, 1950·Science·A Keys

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Citations

Dec 4, 2009·PLoS Computational Biology·Albert A de GraafBen van Ommen
Oct 1, 2008·Genes & Nutrition·Ben van OmmenHannelore Daniel
Jun 26, 2012·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Ola WallengrenKent Lundholm
Feb 24, 2010·IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society·Kevin D Hall
Aug 1, 2018·International Journal of Molecular Sciences·Adrian P DuvalOlivier Dormond
Sep 22, 2018·Current Opinion in Supportive and Palliative Care·Sami AntounEmilie Lanoy
Apr 2, 2019·Journal of Cachexia, Sarcopenia and Muscle·Sami AntounDidier Debieuvre
May 11, 2010·PLoS Computational Biology·Erika Cerasti, Alessandro Treves
Jan 19, 2018·Nature Reviews. Disease Primers·Vickie E BaracosKenneth C H Fearon
Sep 16, 2015·Theoretical Biology & Medical Modelling·Douglas E FriesenJack A Tuszynski
Sep 29, 2020·Journal of Cachexia, Sarcopenia and Muscle·Brennan OlsonAaron J Grossberg
Jan 11, 2013·International Journal of Food Sciences and Nutrition·Alessio MolfinoAlessandro Laviano
Nov 3, 2016·European Journal of Clinical Nutrition·S A PurcellC M Prado
Jun 26, 2018·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Esra CitakOmer Uzel
Jul 2, 2020·Journal of Clinical Medicine·Suzan Farhang-Sardroodi, Kathleen P Wilkie
Apr 4, 2021·International Journal of Molecular Sciences·Antonio MaccioClelia Madeddu
Apr 30, 2021·Translational Oncology·Anastasia KottorouAspasia Tsezou

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