Computational Modeling of Electrophysiology and Pharmacotherapy of Atrial Fibrillation: Recent Advances and Future Challenges

Frontiers in Physiology
Márcia VagosJussi T Koivumäki

Abstract

The pathophysiology of atrial fibrillation (AF) is broad, with components related to the unique and diverse cellular electrophysiology of atrial myocytes, structural complexity, and heterogeneity of atrial tissue, and pronounced disease-associated remodeling of both cells and tissue. A major challenge for rational design of AF therapy, particularly pharmacotherapy, is integrating these multiscale characteristics to identify approaches that are both efficacious and independent of ventricular contraindications. Computational modeling has long been touted as a basis for achieving such integration in a rapid, economical, and scalable manner. However, computational pipelines for AF-specific drug screening are in their infancy, and while the field is progressing quite rapidly, major challenges remain before computational approaches can fill the role of workhorse in rational design of AF pharmacotherapies. In this review, we briefly detail the unique aspects of AF pathophysiology that determine requirements for compounds targeting AF rhythm control, with emphasis on delimiting mechanisms that promote AF triggers from those providing substrate or supporting reentry. We then describe modeling approaches that have been used to assess the...Continue Reading

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Citations

Jan 10, 2020·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Natalia A TrayanovaAdityo Prakosa
Jan 16, 2020·Annals of Biomedical Engineering·Amin DeyranlouAmir Keshmiri
Nov 10, 2020·Frontiers in Physiology·Márcia R VagosJoakim Sundnes
Sep 8, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Henry SutantoJordi Heijman
Feb 20, 2021·Mathematical Biosciences·Bogdan AmuzescuBeatrice Mihaela Radu
Jul 25, 2021·International Journal of Molecular Sciences·Jieyun BaiJichao Zhao

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Methods Mentioned

BETA
pharmacotherapy
scanning electron microscopy

Software Mentioned

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