Computational modeling to predict the temporal regulation of chondrocyte metabolism in response to various dynamic compression regimens

Biomechanics and Modeling in Mechanobiology
B G SengersD L Bader

Abstract

Based on previously published experimental work, computational models were developed to simulate the effect of different dynamic compression regimens on the activity of chondrocytes seeded in agarose constructs. In particular, the balance between proliferation and matrix synthesis can be adjusted by applying different intervals of continuous or intermittent mechanical compression. A phenomenological compartment based-modeling approach was used as first model. A more mechanistic cell cycle model was used as the second model. The compartment-based modeling approach was found to be useful in representing a balance between proliferation and proteoglycan synthesis, when the effect of a certain stimulation protocol is known. In order to predict the response to different intervals of mechanical stimulation, however, a more mechanistic cell cycle-based approach is required. The cell cycle model supports an important role of the onset of loading. In addition, an inhibitory effect of further loading is required, which is more likely to be related to cell cycle progression velocity than to a decreased probability of commitment to the cell cycle. The mechanisms behind this inhibitory effect and the computational implementation, however, re...Continue Reading

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Citations

Nov 4, 2006·Biomechanics and Modeling in Mechanobiology·Gerard A Ateshian
Nov 14, 2007·Biomechanics and Modeling in Mechanobiology·Julien PierreRobert E Guldberg
Mar 12, 2009·Journal of Biomechanical Engineering·Timothy P FicklinStephen M Klisch
Mar 21, 2008·Journal of Theoretical Biology·Hanna IsakssonKeita Ito
Aug 5, 2010·Journal of Tissue Engineering and Regenerative Medicine·Arzu TasciPhilippe Büchler
Sep 14, 2011·Journal of Biomedical Materials Research. Part a·G KrishnamurithyT Kamarul

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