Computational modeling: What does it tell us about atrial fibrillation therapy?

International Journal of Cardiology
Eleonora GrandiJordi Heijman

Abstract

Atrial fibrillation (AF) is a complex cardiac arrhythmia with diverse etiology that negatively affects morbidity and mortality of millions of patients. Technological and experimental advances have provided a wealth of information on the pathogenesis of AF, highlighting a multitude of mechanisms involved in arrhythmia initiation and maintenance, and disease progression. However, it remains challenging to identify the predominant mechanisms for specific subgroups of AF patients, which, together with an incomplete understanding of the pleiotropic effects of antiarrhythmic therapies, likely contributes to the suboptimal efficacy of current antiarrhythmic approaches. Computer modeling of cardiac electrophysiology has advanced in parallel to experimental research and provides an integrative framework to attempt to overcome some of these challenges. Multi-scale cardiac modeling and simulation integrate structural and functional data from experimental and clinical work with knowledge of atrial electrophysiological mechanisms and dynamics, thereby improving our understanding of AF mechanisms and therapy. In this review, we describe recent advances in our quantitative understanding of AF through mathematical models. We discuss computatio...Continue Reading

Citations

Oct 15, 2019·Frontiers in Physiology·Laura Martinez-MateuAdemuyiwa S Aromolaran
Sep 8, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Henry SutantoJordi Heijman
Feb 20, 2021·Mathematical Biosciences·Bogdan AmuzescuBeatrice Mihaela Radu
Mar 23, 2021·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Ali GharaviriUlrich Schotten
May 19, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Marinela Couselo-SeijasSonia Eiras
May 30, 2021·Current Cardiology Reports·Xiao-Dong ZhangNipavan Chiamvimonvat

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