PMID: 9191891May 1, 1997Paper

Computational modelling of low-energy electron-induced DNA damage by early physical and chemical events

International Journal of Radiation Biology
H NikjooM Terrissol

Abstract

Modelling and calculations are presented as a first step towards mechanistic interpretation and prediction of radiation effects based on the spectrum of initial DNA damage produced by low energy electrons (100 eV-4.5 keV) that can be compared with experimental information. Relative yields of single and clustered strand breaks are presented in terms of complexity and source of damage, either by direct energy deposition or by reaction of OH radicals, and dependence on the activation probability of OH radicals and the amount of energy required to give a single strand break (ssb). Data show that the majority of interactions in DNA do not lead to damage in the form of strand breaks and when they do occur, they are most frequently simple ssb. However, for double-strand breaks (dsb), a high proportion (approximately 30%) are of more complex forms, even without considering additional complexity from base damage. The greater contribution is from direct interactions in the DNA but reactions of OH radicals add substantially to this, both in terms of the total number of breaks and in increasing the complexity within a cluster. It has been shown that the lengths of damaged segments of DNA from individual electron tracks tend to be short, in...Continue Reading

References

Feb 23, 1979·Radiation and Environmental Biophysics·J D ChapmanC A Tobias
Jul 1, 1992·International Journal of Radiation Biology·V Michalik
Nov 1, 1991·International Journal of Radiation Biology·H NikjooH G Paretzke
Jun 1, 1989·Physics in Medicine and Biology·H NikjooH G Paretzke
Nov 1, 1988·International Journal of Radiation Biology·D Blöcher
Jan 1, 1988·Progress in Nucleic Acid Research and Molecular Biology·J F Ward
Mar 1, 1988·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·D E Charlton, J L Humm
May 1, 1983·Physics in Medicine and Biology·D T Goodhead, D J Brenner
Apr 30, 1982·Science·R E DickersonM L Kopka
Feb 1, 1995·International Journal of Radiation Biology·Y UmraniaJ M Goodfellow
Nov 1, 1994·International Journal of Radiation Biology·J F Ward
Nov 1, 1994·International Journal of Radiation Biology·M Terrissol
Nov 1, 1994·International Journal of Radiation Biology·M ZaiderA Fung
Nov 1, 1994·International Journal of Radiation Biology·K M PriseB D Michael
May 1, 1993·International Journal of Radiation Biology·D T GoodheadR Cox
Jan 1, 1993·Advances in Radiation Biology·A Chatterjee, W R Holley

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Citations

May 11, 2000·Journal of Radiation Research·H NikjooB A Bridges
May 11, 2000·Journal of Radiation Research·D T Goodhead
May 11, 2000·Journal of Radiation Research·I YoshikawaM Hoshi
Aug 9, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·G L DianovD T Goodhead
Mar 15, 2005·International Journal of Radiation Biology·Tim GoorleyHooshang Nikjoo
Apr 28, 2006·International Journal of Radiation Biology·Ganesh Chandra Jagetia, V A Venkatesha
Dec 14, 2006·Radiation Protection Dosimetry·Th Elsässer, M Scholz
Dec 15, 2006·Radiation Protection Dosimetry·Werner FriedlandMarco Liotta
Feb 13, 2014·International Journal of Radiation Biology·Ya-Yun HsiaoChuan-Jong Tung
Sep 21, 2013·Physics in Medicine and Biology·Ramin M AbolfathRavinder Nath
Jun 20, 2014·Physical Chemistry Chemical Physics : PCCP·R A RosenbergR Naaman
Sep 16, 2017·Physical Chemistry Chemical Physics : PCCP·Marc Benjamin HahnHeinz Sturm
Oct 27, 2017·Radiation Research·Tamara BuchThomas Friedrich
Oct 31, 2018·Scientific Reports·Thomas FriedrichGünther Dollinger
Feb 13, 2019·Cancers·Stephen J McMahon, Kevin M Prise
Feb 14, 2020·International Journal of Radiation Biology·Hossein MoeiniReza Taleei
Feb 6, 2020·Radiation Research·Caterina MoniniMichael Beuve
Oct 18, 2001·Radiation Research·M WeinfeldR A Britten
May 15, 2002·Radiation Research·Betsy M SutherlandJacques Laval
Mar 24, 1998·Physics in Medicine and Biology·M A HillD T Goodhead
Feb 6, 2007·Radiation Protection Dosimetry·Dudley T Goodhead
May 6, 2003·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·K H ChadwickM J P Brugmans
Feb 12, 2009·International Journal of Radiation Biology·Peter O'Neill, Peter Wardman
Sep 29, 2005·Radiation Research·J H MillerM Dupuis
Apr 30, 2009·Environmental and Molecular Mutagenesis·Yoshio TakashimaMasamitsu Honma
Aug 31, 2007·International Journal of Radiation Biology·A EschenbrennerA Chetioui
Nov 16, 2011·International Journal of Radiation Biology·Hooshang Nikjoo, Peter Girard
Dec 21, 2011·Proceedings of the National Academy of Sciences of the United States of America·Teresa NeumaierSylvain V Costes
Apr 30, 2010·Physics in Medicine and Biology·Hooshang Nikjoo, Lennart Lindborg
Jun 16, 2012·Computational and Mathematical Methods in Medicine·Zdenka KuncicSébastien Incerti
Jan 15, 2010·Physics in Medicine and Biology·G GartyB Grosswendt
Nov 2, 2011·International Journal of Radiation Biology·Aimee L McNamaraAnatoly B Rosenfeld

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