Computational modelling of magnesium stent mechanical performance in a remodelling artery: Effects of multiple remodelling stimuli

International Journal for Numerical Methods in Biomedical Engineering
Enda L BolandP E McHugh

Abstract

Significant research has been conducted in the area of coronary stents/scaffolds made from resorbable metallic and polymeric biomaterials. These next-generation bioabsorbable stents have the potential to completely revolutionise the treatment of coronary artery disease. The primary advantage of resorbable devices over permanent stents is their temporary presence which, from a theoretical point of view, means only a healed coronary artery will be left behind following degradation of the stent potentially eliminating long-term clinical problems associated with permanent stents. The healing of the artery following coronary stent/scaffold implantation is crucial for the long-term safety of these devices. Computational modelling can be used to evaluate the performance of complex stent devices in silico and assist in the design and development and understanding of the next-generation resorbable stents. What is lacking in computational modelling literature is the representation of the active response of the arterial tissue in the weeks and months following stent implantation, ie, neointimal remodelling, in particular for the case of biodegradable stents. In this paper, a computational modelling framework is developed, which accounts f...Continue Reading

References

Dec 11, 1999·JAMA : the Journal of the American Medical Association·A M MalekS Izumo
Apr 17, 2002·Medical & Biological Engineering & Computing·D LacroixD Marsh
Dec 29, 2004·Computer Methods in Biomechanics and Biomedical Engineering·D R HoseP V Lawford
Apr 19, 2005·Journal of Theoretical Biology·M J Gómez-BenitoM Doblaré
Jun 17, 2005·Journal of Biomechanics·C LallyP J Prendergast
Jun 21, 2005·Journal of the American College of Cardiology·Andrew T L OngPatrick W Serruys
Jul 12, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Gerhard A HolzapfelPeter Regitnig
Oct 6, 2005·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Peter ZartnerMichael Weyand
Mar 1, 2006·Journal of Clinical Pathology·A K Mitra, D K Agrawal
Jul 4, 2006·Journal of the American College of Cardiology·Michael JonerRenu Virmani
Sep 26, 2006·Journal of Biomechanical Engineering·Julian BedoyaJames E Moore
Mar 22, 2007·Medical & Biological Engineering & Computing·Lucas H TimminsJames E Moore
Oct 9, 2007·Journal of Biomechanics·Matthieu De BeulePascal Verdonck
Oct 10, 2009·Acta Biomaterialia·H HermawanD Mantovani
Dec 25, 2009·Circulation. Cardiovascular Interventions·John A Ormiston, Patrick W S Serruys
Mar 10, 2010·Computers in Biology and Medicine·Jonathan Murphy, Fergal Boyle
May 19, 2010·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·C J BoyleP J Prendergast
May 22, 2010·JACC. Cardiovascular Interventions·Giulio GuagliumiUNKNOWN ODESSA Trial Investigators
Sep 10, 2010·Journal of the American College of Cardiology·Scot Garg, Patrick W Serruys
Oct 16, 2010·Journal of the American College of Cardiology·David R HolmesDavid J Moliterno
Sep 1, 2009·Cellular and Molecular Bioengineering·Minki HwangRoger Tran-Son-Tay
Jun 15, 2011·Acta Biomaterialia·J A GroganP E McHugh
Jul 26, 2011·Annals of Biomedical Engineering·Stefano MorlacchiPatricia Lawford
Sep 29, 2011·Journal of Biomechanical Engineering·Colin J BoylePatrick J Prendergast
Jun 19, 2012·Journal of the Mechanical Behavior of Biomedical Materials·J A GroganP E McHugh
Aug 1, 2012·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Patrick K BowenJaroslaw Drelich
Sep 13, 2012·Computer Methods in Biomechanics and Biomedical Engineering·Houman ZahedmaneshCaitríona Lally
Feb 13, 2013·Journal of Biomechanics·Colin J BoylePatrick J Prendergast
Sep 12, 2014·Annals of Biomedical Engineering·C ConwayP E McHugh
Aug 15, 2015·Annals of Biomedical Engineering·Enda L BolandPeter E McHugh
Dec 19, 2015·Annals of Biomedical Engineering·Peter McHughSean McGinty
Apr 12, 2016·International Journal for Numerical Methods in Biomedical Engineering·Constantine ZakkaroffTim David
Feb 6, 2017·Annals of Biomedical Engineering·Georgia S KaranasiouDimitrios I Fotiadis
Mar 7, 2017·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Ron WaksmanMichael Joner
Apr 15, 2017·Circulation Research·Yohei SotomiPatrick W Serruys
Apr 24, 2017·Acta Biomaterialia·E GalvinC Lally

❮ Previous
Next ❯

Citations

Jan 9, 2020·Biomechanics and Modeling in Mechanobiology·Ran HeYang Liu
Nov 17, 2020·APL Bioengineering·Alberto Redaelli, Emiliano Votta
Apr 13, 2021·International Journal of Pharmaceutics·Alistair McQueenSean McGinty

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Medical Devices : Evidence and Research
Brendan Doyle, David R Holmes
Current Interventional Cardiology Reports
Takafumi TsujiHiromu Uehata
© 2021 Meta ULC. All rights reserved