Abstract
Intracellular Ca(2+) dynamics provides excitation-contraction coupling in cardiac myocytes. Under pathological conditions, spontaneous Ca(2+) release events can lead to intracellular Ca(2+) travelling waves, which can break, giving transitory or persistent intracellular re-entrant Ca(2+) scroll waves. Intracellular Ca(2+) waves can trigger cellular delayed after-depolarizations of membrane potential, which if they occur in a cluster of a few hundred neighbouring myocytes may lead to cardiac arrhythmia. Quantitative prediction of the initiation and propagation of intracellular Ca(2+) waves requires the dynamics of Ca(2+)-induced Ca(2+) release, and the intracellular spatial distribution of Ca(2+) release units (CRUs). The spatial distribution of ryanodine receptor clusters within a few sarcomeres was reconstructed directly from confocal imaging measurements. It was then embedded into a three-dimensional ventricular cell model, with a resting membrane potential and simple stochastic Ca(2+)-induced Ca(2+) release dynamics. Isotropic global Ca(2+) wave propagation can be produced within the anisotropic intracellular architecture, by isotropic local Ca(2+) diffusion, and the branching Z-disc structure providing inter Z-disc pathways...Continue Reading
References
Oct 29, 1993·Science·H ChengM B Cannell
Jan 1, 1996·The American Journal of Physiology·H ChengM B Cannell
Aug 1, 1997·Cardiovascular Research·A M Evans, M B Cannell
Jul 24, 1998·Biophysical Journal·J KeizerJ E Pearson
May 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·S P DawsonJ E Pearson
Oct 8, 1999·Biophysical Journal·H IshidaW H Barry
Feb 13, 2001·Biophysical Journal·L T IzuW G Wier
Feb 13, 2001·Biophysical Journal·L T IzuC W Balke
Jun 20, 2001·Nature Reviews. Molecular Cell Biology·M J BerridgeM D Bootman
Apr 28, 2004·Biophysical Journal·R Thul, M Falcke
Oct 22, 2004·American Journal of Physiology. Cell Physiology·Jun-ichi OkadaToshiaki Hisada
Dec 3, 2005·Progress in Biophysics and Molecular Biology·R HinchR L Winslow
Jul 20, 2006·Quarterly Reviews of Biophysics·Yoram Rudy, Jonathan R Silva
Aug 5, 2006·Circulation Research·D A EisnerA W Trafford
Jan 24, 2007·Oral Microbiology and Immunology·J C Machado de OliveiraA S Rosado
Sep 13, 2007·Proceedings of the National Academy of Sciences of the United States of America·Christian SoellerMark B Cannell
Oct 5, 2007·Progress in Biophysics and Molecular Biology·Alan P BensonArun V Holden
Jan 14, 2009·Experimental Physiology·Christian SoellerMark B Cannell
Mar 20, 2009·Experimental Physiology·Clive H OrchardFabien Brette
Mar 31, 2009·Nature Medicine·Hiroshi WatanabeBjörn C Knollmann
Citations
Apr 30, 2014·The Journal of General Physiology·Michael D SternVictor A Maltsev
Nov 13, 2015·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Raimond L WinslowJoseph L Greenstein
Feb 17, 2018·Physical Review. E·Xiang LiJianwei Shuai
Sep 1, 2017·PLoS Computational Biology·Michael A ColmanAshraf Kitmitto
Mar 16, 2011·Alternatives to Laboratory Animals : ATLA·Arun V Holden
Nov 9, 2018·Frontiers in Physiology·Izzy JayasingheChristian Soeller