Computational modelling suggests that temporal integration results from synaptic adaptation in auditory cortex

The European Journal of Neuroscience
Patrick J C MayHannu Tiitinen

Abstract

Incoming sounds are represented in the context of preceding events, and this requires a memory mechanism that integrates information over time. Here, it was demonstrated that response adaptation, the suppression of neural responses due to stimulus repetition, might reflect a computational solution that auditory cortex uses for temporal integration. Adaptation is observed in single-unit measurements as two-tone forward masking effects and as stimulus-specific adaptation (SSA). In non-invasive observations, the amplitude of the auditory N1m response adapts strongly with stimulus repetition, and it is followed by response recovery (the so-called mismatch response) to rare deviant events. The current computational simulations described the serial core-belt-parabelt structure of auditory cortex, and included synaptic adaptation, the short-term, activity-dependent depression of excitatory corticocortical connections. It was found that synaptic adaptation is sufficient for columns to respond selectively to tone pairs and complex tone sequences. These responses were defined as combination sensitive, thus reflecting temporal integration, when a strong response to a stimulus sequence was coupled with weaker responses both to the time-rev...Continue Reading

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Citations

Dec 15, 2015·Neural Computation·Johan WestöHannu Tiitinen
Oct 27, 2015·Current Opinion in Neurobiology·Robert C Froemke, Christoph E Schreiner
Jul 31, 2016·Hearing Research·Johan Westö, Patrick J C May
Mar 14, 2017·PLoS Computational Biology·Tohar S Yarden, Israel Nelken
Apr 21, 2017·Nature Communications·Claire ChambersDaniel Pressnitzer
Dec 6, 2017·Scientific Reports·Adam Ponzi
Sep 12, 2015·Journal of Neurophysiology·Björn HerrmannEdward L Bartlett
Sep 21, 2018·Frontiers in Neural Circuits·Pawel KudelaWilliam Stanley Anderson
Oct 20, 2017·Integrative and Comparative Biology·Kim L HokeDaizaburo Shizuka
Jun 2, 2017·Journal of Neurophysiology·Elizabeth A K PhillipsAndrea R Hasenstaub
Feb 11, 2020·Frontiers in Computational Neuroscience·Isma ZulfiqarElia Formisano
Mar 30, 2021·Frontiers in Neural Circuits·Alejandro Tabas, Katharina von Kriegstein
Sep 11, 2021·Scientific Reports·Natacha Vanattou-SaïfoudineGiacomo Indiveri
Sep 7, 2021·Frontiers in Human Neuroscience·Peter A RobinsonTara Babaie-Janvier

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