Computational Pre-surgical Planning of Arterial Patch Reconstruction: Parametric Limits and In Vitro Validation

Annals of Biomedical Engineering
S Samaneh LashkariniaKerem Pekkan

Abstract

Surgical treatment of congenital heart disease (CHD) involves complex vascular reconstructions utilizing artificial and native surgical materials. A successful surgical reconstruction achieves an optimal hemodynamic profile through the graft in spite of the complex post-operative vessel growth pattern and the altered pressure loading. This paper proposes a new in silico patient-specific pre-surgical planning framework for patch reconstruction and investigates its computational feasibility. The proposed protocol is applied to the patch repair of main pulmonary artery (MPA) stenosis in the Tetralogy of Fallot CHD template. The effects of stenosis grade, the three-dimensional (3D) shape of the surgical incision and material properties of the artificial patch are investigated. The release of residual stresses due to the surgical incision and the extra opening of the incision gap for patch implantation are simulated through a quasi-static finite-element vascular model with shell elements. Implantation of different unloaded patch shapes is simulated. The patched PA configuration is pressurized to the physiological post-operative blood pressure levels of 25 and 45 mmHg and the consequent post-operative stress distributions and patched...Continue Reading

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Citations

Feb 5, 2021·Journal of Biomechanics·S Samaneh LashkariniaKerem Pekkan
Apr 20, 2021·Computational and Mathematical Methods in Medicine·M Conijn, G J Krings

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