Computational principles of neural adaptation for binaural signal integration

PLoS Computational Biology
Timo OessHeiko Neumann

Abstract

Adaptation to statistics of sensory inputs is an essential ability of neural systems and extends their effective operational range. Having a broad operational range facilitates to react to sensory inputs of different granularities, thus is a crucial factor for survival. The computation of auditory cues for spatial localization of sound sources, particularly the interaural level difference (ILD), has long been considered as a static process. Novel findings suggest that this process of ipsi- and contra-lateral signal integration is highly adaptive and depends strongly on recent stimulus statistics. Here, adaptation aids the encoding of auditory perceptual space of various granularities. To investigate the mechanism of auditory adaptation in binaural signal integration in detail, we developed a neural model architecture for simulating functions of lateral superior olive (LSO) and medial nucleus of the trapezoid body (MNTB) composed of single compartment conductance-based neurons. Neurons in the MNTB serve as an intermediate relay population. Their signal is integrated by the LSO population on a circuit level to represent excitatory and inhibitory interactions of input signals. The circuit incorporates an adaptation mechanism opera...Continue Reading

References

Sep 1, 1992·Hearing Research·M ZacksenhouseC Tsuchitani
Jan 12, 1973·Nature·B Sakitt
May 1, 1968·Journal of Neurophysiology·J C Boudreau, C Tsuchitani
Jan 1, 1983·Experimental Brain Research·D Caird, R Klinke
Nov 1, 1995·Die Naturwissenschaften·B Grothe, T J Park
Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·P A SalinR A Nicoll
Feb 21, 1998·Journal of Neurophysiology·P X Joris, T C Yin
Jun 26, 1998·Journal of Neurophysiology·M ZacksenhouseC Tsuchitani
Jun 28, 2000·Proceedings of the National Academy of Sciences of the United States of America·D McLaughlinD J Wielaard
Feb 5, 2002·Annual Review of Physiology·Robert S Zucker, Wade G Regehr
Nov 16, 2005·Nature Neuroscience·Isabel DeanDavid McAlpine
Dec 29, 2007·Hearing Research·Thomas J ParkBenedikt Grothe
May 9, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniel J TollinJeffrey J Tsai
Jul 4, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael PeckaBenedikt Grothe
Sep 30, 2008·Nature Neuroscience·Paul V Watkins, Dennis L Barbour
Feb 1, 1948·Journal of Comparative and Physiological Psychology·L A JEFFRESS
Nov 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bo WenBertrand Delgutte
Jul 29, 2010·Physiological Reviews·Benedikt GrotheDavid McAlpine
Mar 19, 2011·Neuroscience and Biobehavioral Reviews·Andrew J KingVictoria M Bajo
Oct 12, 2011·Brain Research·Iiro P JääskeläinenMikko Sams
Oct 28, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Peter HeilDexter R F Irvine
Nov 24, 2011·Nature Reviews. Neuroscience·Matteo Carandini, David J Heeger
Dec 1, 2009·IEEE Transactions on Biomedical Circuits and Systems· Bo Wen, K Boahen
Dec 28, 2017·PLoS Computational Biology·Go AshidaJutta Kretzberg
May 31, 2018·Scientific Reports·A LingnerB Grothe

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