Computational role of large receptive fields in the primary somatosensory cortex.

Journal of Neurophysiology
Guglielmo FoffaniKaren A Moxon

Abstract

Computational studies are challenging the intuitive view that neurons with broad tuning curves are necessarily less discriminative than neurons with sharp tuning curves. In the context of somatosensory processing, broad tuning curves are equivalent to large receptive fields. To clarify the computational role of large receptive fields for cortical processing of somatosensory information, we recorded ensembles of single neurons from the infragranular forelimb/forepaw region of the rat primary somatosensory cortex while tactile stimuli were separately delivered to different locations on the forelimbs/forepaws under light anesthesia. We specifically adopted the perspective of individual columns/segregates receiving inputs from multiple body location. Using single-trial analyses of many single-neuron responses, we obtained two main results. 1) The responses of even small populations of neurons recorded from within the same estimated column/segregate can be used to discriminate between stimuli delivered to different surround locations in the excitatory receptive fields. 2) The temporal precision of surround responses is sufficiently high for spike timing to add information over spike count in the discrimination between surround locat...Continue Reading

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Citations

Aug 30, 2011·Proceedings of the National Academy of Sciences of the United States of America·Alessandro ScaglioneGuglielmo Foffani
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Jan 9, 2019·Frontiers in Neural Circuits·Ayako HayashiKenichi Ohki

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