Computational simulation of flow in the end-to-end anastomosis of a rigid graft and a compliant artery

ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Y Qiu, J M Tarbell

Abstract

Implanted vascular grafts often fail because of the development of intimal hyperplasia in the anastomotic region, and compliance mismatch between the host artery and graft exacerbates the problem. This study focused on the effects of radial artery wall motion and phase angle between pressure and flow waves (impedance phase angle [IPA]) on the wall shear rate (WSR) behavior near end-to-end vascular graft anastomoses models connecting rigid grafts and compliant arteries. A finite element model with transient flow and moving boundaries was set up to simulate oscillatory flow through a 16% undersized (mean) diameter graft model. During the simulations, different artery diameter variations (DVs) over a cycle (DV) and IPAs were simulated in the physiologic range for an oscillatory flow (mean Re = 150, peak Re = 300, unsteadiness parameter alpha = 3.9). The results show that for normal physiologic conditions (DV = 6%, IPA = -45 degrees) in a 16% undersized graft, the minimum distal mean WSR is reduced by 60% compared to steady flow at the mean Re; the minimum distal WSR amplitude increases 50% when IPA changes from -5 degrees to -85 degrees, and increases 60% when DV changes from 2% to 10%. This indicates that compliance mismatch indu...Continue Reading

Citations

Mar 18, 2005·Biomechanics and Modeling in Mechanobiology·Francesco Migliavacca, Gabriele Dubini
Apr 8, 2010·Cell Biochemistry and Biophysics·Qingjun YouZhenya Shen
May 3, 2000·Journal of Biomechanical Engineering·Y Qiu, J M Tarbell
Jan 6, 2012·Computer Methods and Programs in Biomedicine·Amal Ahmed OwidaYos S Morsi
Dec 11, 2014·Materials Science & Engineering. C, Materials for Biological Applications·J Kucinska-LipkaM Sienkiewicz
Jun 2, 2009·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Haiying HuangYasuhide Nakayama
Apr 22, 2016·Journal of Biomedical Materials Research. Part a·Josh D Erndt-MarinoMariah S Hahn
Mar 23, 2001·Journal of Biomaterials Applications·H J SalacinskiR J Carson
Jul 27, 2002·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Paul C HoRichard W Nesto
May 8, 2003·Journal of Biomedical Materials Research. Part a·Hiromichi SonodaTakehisa Matsuda
Feb 17, 2005·Journal of Biomedical Materials Research. Part a·Takehisa MatsudaSatoru Kidoaki
May 15, 2015·Physics in Medicine and Biology·Lili NiuHairong Zheng

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved