PMID: 8945921Nov 1, 1996Paper

Computational simulations of local vascular heparin deposition and distribution

The American Journal of Physiology
M A Lovich, Elazer R Edelman

Abstract

Local vascular drug delivery systems provide elevated concentrations in target arterial tissues while minimizing systemic side effects; however, definition of their precise pharmacokinetics remains elusive. The standard labeled tracer assays used in experimental vascular pharmacokinetic studies of these systems are limited because they quantify the arterial average drug concentration as opposed to transmural concentration profiles, require many animal experiments to elucidate the time-varying deposition, and track label rather than intact biologically active drug. In this study, computational simulations of drug deposition and distribution in vascular tissues after release from these systems have provided two important insights. First, simulations of arteries that were uniformly loaded with heparin predicted that most of the drug is cleared in < 1 h, illustrating the need for sustained modes of delivery. Second, some of the limitations of labeled tracers can be over come by combining experimental data with simulations that provided high spatial resolution. This enabled us to describe the kinetics of the deposited drug and distinguish soluble from reversibly bound and internalized drug within cells. The latter can help different...Continue Reading

Citations

Dec 28, 2012·Annals of Biomedical Engineering·William J DennyMichael T Walsh
Oct 11, 2015·Annals of Biomedical Engineering·Paolo ZuninoFrancesco Migliavacca
Oct 24, 2012·Annals of Biomedical Engineering·Stefano Morlacchi, Francesco Migliavacca
Mar 6, 1998·Nature Biotechnology·E R Edelman, M Lovich
Sep 1, 2012·Biomechanics and Modeling in Mechanobiology·Elena CutrìFrancesco Migliavacca

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