Computational study on monkey VOR adaptation and smooth pursuit based on the parallel control-pathway theory

Journal of Neurophysiology
Hiromitsu TabataM Kawato

Abstract

Much controversy remains about the site of learning and memory for vestibuloocular reflex (VOR) adaptation in spite of numerous previous studies. One possible explanation for VOR adaptation is the flocculus hypothesis, which assumes that this adaptation is caused by synaptic plasticity in the cerebellar cortex. Another hypothesis is the model proposed by Lisberger that assumes that the learning that occurs in both the cerebellar cortex and the vestibular nucleus is necessary for VOR adaptation. Lisberger's model is characterized by a strong positive feedback loop carrying eye velocity information from the vestibular nucleus to the cerebellar cortex. This structure contributes to the maintenance of a smooth pursuit driving command with zero retinal slip during the steady-state phase of smooth pursuit with gain 1 or during the target blink condition. Here, we propose an alternative hypothesis that suggests that the pursuit driving command is maintained in the medial superior temporal (MST) area based on MST firing data during target blink and during ocular following blank, and as a consequence, we assume a much smaller gain for the positive feedback from the vestibular nucleus to the cerebellar cortex. This hypothesis is equivale...Continue Reading

References

Sep 1, 1979·The Journal of Physiology·H Noda, D A Suzuki
Nov 1, 1992·Trends in Neurosciences·M Kawato, H Gomi
Sep 1, 1992·Visual Neuroscience·D BoussaoudL G Ungerleider
Jan 1, 1991·Experimental Brain Research·R G Erickson, P Thier
Jul 1, 1989·Journal of Neurophysiology·H Komatsu, R H Wurtz
Nov 4, 1988·Science·S G Lisberger
Sep 1, 1988·Journal of Neurophysiology·M R Dürsteler, R H Wurtz
Feb 1, 1988·Annals of Neurology·R J Tusa, L G Ungerleider
Jan 1, 1987·Experimental Brain Research·D B Belknap, H Noda
Jun 8, 1986·The Journal of Comparative Neurology·L G Ungerleider, R Desimone
Nov 1, 1986·Journal of Neurophysiology·F A Miles, K Kawano
Nov 1, 1973·Journal of Neurophysiology·S Ron, D A Robinson
May 12, 1972·Brain Research·M Ito
Mar 1, 1984·The Journal of Comparative Neurology·L G UngerleiderM Mishkin
Jan 1, 1981·Annual Review of Neuroscience·F A Miles, S G Lisberger
Jan 1, 1982·Biological cybernetics·M Fujita
Oct 1, 1981·Journal of Neurophysiology·D S ZeeG Gücer
Mar 15, 1980·The Journal of Comparative Neurology·M GlicksteinF Robinson

❮ Previous
Next ❯

Citations

Oct 31, 2007·PLoS Computational Biology·John Porrill, Paul Dean
Feb 2, 2013·Journal of Neurology·Hong-Kyun ParkDavid S Zee
Dec 10, 2003·Annals of the New York Academy of Sciences·Michael J MustariRonald J Tusa
Dec 10, 2003·Annals of the New York Academy of Sciences·Stephan Glasauer
Mar 23, 2012·PloS One·Tadashi Yamazaki, Soichi Nagao
Jun 9, 2006·Progress in Neurobiology·Masao Ito
May 9, 2008·Experimental Brain Research·Sarah MartiStefan Glasauer
Jun 26, 2004·Annual Review of Neuroscience·Edward S BoydenJennifer L Raymond
Mar 10, 2015·Journal of Clinical Neurology·Seol Hee BaekJi Soo Kim
Feb 13, 2003·Annals of the New York Academy of Sciences·Yutaka Hirata, Stephen M Highstein
Dec 2, 2005·Journal of Neurophysiology·Pablo M BlazquezStephen M Highstein
Apr 4, 2008·Journal of Neurophysiology·Ulrich NudingStefan Glasauer
Mar 13, 2013·Strabismus·Christopher M KnappIrene Gottlob
Jul 1, 2020·Neuroscience·Mitsuo KawatoTerry Sanger

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.