Computational systems biology approach to identify novel pharmacological targets for diabetic retinopathy

Biochemical Pharmacology
Chiara Bianca Maria PlataniaClaudio Bucolo

Abstract

Diabetic retinopathy was included by the World Health Organization in the eye disease priority list. Up to now, only proliferative diabetic retinopathy can be treated with approved drugs, such as intravitreal anti-vascular endothelial growth factor (VEGF) agents or steroids. In this perspective, there is the urgent need to explore novel pharmacological targets for treatment of diabetic retinopathy. Drug discovery todays exploits the noticeable ability of computational systems biology methods to identify novel drug targets in complex pathologies bearing multifactorial etiology and wide and varying symptomatology. This is especially true for diseases, where the identification of specific molecular mechanisms, and thus drug targets, is a challenging, when not impossible, task. Within this framework, we applied a systems biology approach to identify novel drug targets for diabetic retinopathy. The complexity of diabetic retinopathy was investigated through the analysis of transcriptomics data, retrieved from Gene Expression Omnibus Dataset repository (GEO) datasets. Analysis of GEO datasets was carried out with an enrichment-information approach, which gave as output a series of complex gene-pathway and drug-gene networks. Analysis...Continue Reading

Citations

Mar 19, 2019·British Journal of Pharmacology·Chiara Bianca Maria PlataniaClaudio Bucolo
May 23, 2019·Investigative Ophthalmology & Visual Science·Rupal MorjariaUNKNOWN SOMNUS Study Group
Dec 18, 2019·Pharmacological Reviews·Jhana O HendrickxStuart Maudsley
Jul 7, 2019·Journal of Clinical Medicine·Nikhil SahajpalRenu A Kowluru
Nov 5, 2020·Expert Opinion on Drug Delivery·Deep Shikha SharmaSukriti Vishwas
Dec 19, 2020·International Journal of Molecular Sciences·Vincenza BonfiglioClaudio Bucolo
Feb 9, 2021·Global Challenges·Hanaa A GalebJohn G Hardy
Apr 27, 2019·European Journal of Pharmacology·Yasuhiro NakagamiTatsuya Inoue
Feb 20, 2021·Biochemical Pharmacology·Maria Consiglia TrottaSettimio Rossi
Mar 11, 2021·Drug Metabolism Reviews·Shreya R SavlaYogesh A Kulkarni
Apr 4, 2021·Journal of Clinical Medicine·Warren W PanJennifer L Harder
Nov 13, 2021·Experimental and Therapeutic Medicine·Lihui SunZhongfu Zuo
Apr 23, 2019·European Journal of Pharmacology·Jing-Jie PengXiao-Bo Xia

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