Computationally Modeling Lipid Metabolism and Aging: A Mini-review

Computational and Structural Biotechnology Journal
Mark T Mc Auley, Kathleen M Mooney

Abstract

One of the greatest challenges in biology is to improve the understanding of the mechanisms which underpin aging and how these affect health. The need to better understand aging is amplified by demographic changes, which have caused a gradual increase in the global population of older people. Aging western populations have resulted in a rise in the prevalence of age-related pathologies. Of these diseases, cardiovascular disease is the most common underlying condition in older people. The dysregulation of lipid metabolism due to aging impinges significantly on cardiovascular health. However, the multifaceted nature of lipid metabolism and the complexities of its interaction with aging make it challenging to understand by conventional means. To address this challenge computational modeling, a key component of the systems biology paradigm is being used to study the dynamics of lipid metabolism. This mini-review briefly outlines the key regulators of lipid metabolism, their dysregulation, and how computational modeling is being used to gain an increased insight into this system.

References

Aug 1, 1992·Metabolism: Clinical and Experimental·P MårinP Björntorp
Oct 7, 1988·JAMA : the Journal of the American Medical Association·M A AustinR M Krauss
Mar 20, 1986·The New England Journal of Medicine·S M Grundy
Nov 1, 1985·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·S M GrundyD W Bilheimer
Nov 9, 1972·The New England Journal of Medicine·R G Brodows, R G Campbell
Dec 1, 1981·Digestive Diseases and Sciences·P R Holt, A A Dominguez
May 24, 1983·Biochimica Et Biophysica Acta·R W Mahley, T L Innerarity
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·D K SpadyJ M Dietschy
May 1, 1983·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·R D AbbottC LaRue
Feb 27, 1984·The American Journal of Medicine·W P Castelli
May 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·G RoglerG Schmitz
Jan 1, 1994·Nature Genetics·F SchächterD Cohen
May 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·H GyllingT A Miettinen
Jul 1, 1997·The Proceedings of the Nutrition Society·R J Havel
Jan 16, 1998·Prostaglandins, Leukotrienes, and Essential Fatty Acids·K C HayesA Pronczuk
Oct 2, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S D TurleyJ M Dietschy
Oct 8, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·M Dobiásová, J J Frohlich
Oct 7, 2000·Journal of the American College of Nutrition·D J McNamara
Nov 23, 2000·Nature·T B Kirkwood, S N Austad
Mar 7, 2001·Frontiers in Bioscience : a Journal and Virtual Library·M M HussainN Z Jamali
Mar 27, 2001·Current Opinion in Lipidology·G S Shelness, J A Sellers
Apr 11, 2001·Journal of the American College of Nutrition·F B HuW C Willett
Nov 10, 2001·Annual Review of Genomics and Human Genetics·T IdekerL Hood
Apr 6, 2002·American Journal of Physiology. Endocrinology and Metabolism·Michelle Z Tucker, Lorraine P Turcotte
Aug 17, 2002·Science·Michael B ElowitzPeter S Swain
Oct 16, 2003·JAMA : the Journal of the American Medical Association·Nir BarzilaiAlan R Shuldiner
May 4, 2004·Annals of Medicine·Albert K GroenFolkert Kuipers
Mar 1, 2005·Cell·Thomas B L Kirkwood
Sep 3, 2005·Biochimica Et Biophysica Acta·P R Shorten, G C Upreti
Feb 24, 2006·Nature Reviews. Molecular Cell Biology·Andrew R Joyce, Bernhard Ø Palsson
Nov 10, 2006·Annals of Human Biology·P P SinghS S Mastana
Dec 6, 2006·Essays in Biochemistry·Keith N FraynHannele Yki-Järvinen

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Citations

Apr 30, 2015·Metabolites·Mark T Mc AuleyStephen J Wilkinson
Jan 31, 2016·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Kathleen M MooneyMark T Mc Auley
Oct 13, 2016·Frontiers in Molecular Biosciences·Vera SchützholdEdda Klipp
Dec 23, 2016·Briefings in Bioinformatics·Mark T Mc AuleyJ Enrique Salcedo-Sora
Feb 9, 2017·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Samia BouamamaSid Ahmed Merzouk
Jun 15, 2018·Journal of Biophotonics·Irina Yu YaninaValery V Tuchin
Nov 3, 2016·The Proceedings of the Nutrition Society·A E MorganM T Mc Auley
Jan 28, 2020·Nutrition Research Reviews·Mark Tomás Mc Auley
Feb 6, 2020·Expert Review of Gastroenterology & Hepatology·Hugo A PennyDavid S Sanders
Oct 12, 2018·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Parya AghasafariRamana Pidaparti
May 1, 2018·The Proceedings of the Nutrition Society·A E MorganM T Mc Auley
Nov 30, 2018·PloS One·Godfred AgongoUNKNOWN as members of AWI-Gen and the H3Africa Consortium
Jan 26, 2017·Frontiers in Cell and Developmental Biology·Pushpendra Singh
Oct 7, 2015·Briefings in Bioinformatics·Andrew PartonSteven Watterson
Nov 1, 2016·Expert Review of Endocrinology & Metabolism·Amy MorganMark Mc Auley
Jan 6, 2021·Annual Review of Food Science and Technology·Steven Le FeunteunGeorge van Aken
Oct 6, 2020·Aging and Disease·Peng ZhangWei Hu
Dec 22, 2021·WIREs Mechanisms of Disease·Mark Tomás Mc Auley

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Methods Mentioned

BETA
lipidation
ChIP-seq

Software Mentioned

BioModels
SBML

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