Computed tomographic attenuation value of coronary atherosclerotic plaques with different tube voltage: an ex vivo study

Journal of Computer Assisted Tomography
Yutaka TanamiSachio Kuribayashi

Abstract

To compare the diagnostic performance of computed tomographic (CT) attenuation and CT attenuation ratio at different tube voltages for ex vivo plaque characterization. Human coronary arteries were obtained at the time of autopsy in 15 subjects. The coronary arteries were serially cut into 5-mm-long segments and scanned ex vivo using 4 sets of tube voltages and tube currents (80 kV, 660 mA; 100 kV, 500 mA; 120 kV, 400 mA; and 140 kV, 340 mA). The CT attenuation value at the center of each plaque was obtained, and the ratio of the CT attenuation value at the 80-kV setting divided by that at the 140-kV setting (Hounsfield ratio [HR], 80:140) was calculated. Separate receiver operating characteristic (ROC) analyses were used to assess the usefulness of the CT attenuation value and the 80:140 HR for the differential diagnosis of lipid-rich plaques from other types of plaques. A total of 93 coronary plaques were detected macroscopically. Histological examination revealed 39 lipid-rich, 24 calcified, and 30 fibrotic plaques. At all the tube voltages, the CT attenuation values of the lipid-rich plaques were lower than those of the calcified plaques, whereas the CT attenuation values of the lipid-rich and fibrotic plaques overlapped. An...Continue Reading

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Citations

Aug 9, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Tsunenari SoedaYoshihiko Saito
Nov 1, 2012·AJR. American Journal of Roentgenology·Rozemarijn VliegenthartU Joseph Schoepf
Oct 1, 2010·Medical Physics·Narinder S PaulAli Ursani
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Nov 10, 2015·Expert Review of Cardiovascular Therapy·Ibrahim DanadJames K Min
Oct 3, 2015·Medical Physics·Rezvan Ravanfar HaghighiSudhir Arava
Nov 14, 2017·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Kevin KaliszPrabhakar Rajiah
Feb 16, 2019·Circulation. Cardiovascular Interventions·Shunsuke ImaiHitoshi Matsuo
Feb 15, 2019·Journal of Computer Assisted Tomography·Takanori MasudaKazuo Awai
Feb 16, 2017·Journal of Thoracic Imaging·Lukas LengaJulian L Wichmann
Sep 15, 2016·Heart·Harjit ChahalMario J Garcia
Jul 1, 2016·Current Cardiovascular Imaging Reports·Amita SinghAmit R Patel
Jul 22, 2018·The International Journal of Cardiovascular Imaging·Masafumi KidohYasuyuki Yamashita
Nov 18, 2020·The International Journal of Cardiovascular Imaging·Breda HennesseyJavier Escaned

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