Computed tomographic colonography compared with colonoscopy in patients at increased risk for colorectal cancer

Gastroenterology
Rogier E Van GelderJaap Stoker

Abstract

To date, computed tomographic (CT) colonography has been compared with an imperfect test, colonoscopy, and has been mainly assessed in patients with positive screening test results or symptoms. Therefore, the available data may not apply to screening of patients with a personal or family history of colorectal polyps or cancer (increased risk). We prospectively investigated the ability of CT colonography to identify individuals with large (>or=10 mm) colorectal polyps in consecutive patients at increased risk for colorectal cancer. A total of 249 consecutive patients at increased risk for colorectal cancer underwent CT colonography before colonoscopy. Two reviewers interpreted CT colonography examinations independently. Sensitivity, specificity, and predictive values were determined after meticulous matching of CT colonography with colonoscopy. Unexplained large false-positive findings were verified with a second-look colonoscopy. In total, 31 patients (12%) had 48 large polyps at colonoscopy. This included 8 patients with 8 large polyps that were overlooked initially and detected at the second-look colonoscopy. In 6 of 8 patients, the missed polyp was the only large lesion. With CT colonography, 84% of patients (26/31) with lar...Continue Reading

References

Nov 21, 1990·Journal of the National Cancer Institute·L J HixsonH Garewal
Nov 24, 1999·The New England Journal of Medicine·H M FenlonJ T Ferrucci
Feb 24, 2001·Endoscopy·J H Bond
Mar 16, 2002·Clinical Endocrinology·P J Jenkins, P D Fairclough
Jul 2, 2002·Radiology·Rogier E van GelderJaap Stoker
Aug 14, 2002·Abdominal Imaging·J L FidlerW S Harmsen
Jan 24, 2003·International Journal of Gastrointestinal Cancer·B C PineauD J Vining
Sep 2, 2003·Gastroenterology·C Daniel JohnsonUNKNOWN American College of Radiology Imaging Network A6656
Dec 6, 2003·The New England Journal of Medicine·Perry J PickhardtWilliam R Schindler
Dec 23, 2003·Expert Review of Anticancer Therapy·Angel Ferrández, James A DiSario

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Citations

Feb 19, 2009·European Radiology·Marjolein H LiedenbaumJaap Stoker
Mar 19, 2011·Surgical Endoscopy·Krzysztof LeksowskiJanusz Rudzinski
Jan 1, 2007·Journal of Gastrointestinal Cancer·Catherine T Frenette, Williamson B Strum
Aug 24, 2010·World Journal of Gastroenterology : WJG·Andrea LaghiCesare Hassan
Jul 19, 2012·World Journal of Gastroenterology : WJG·Peter D SiersemaDaniel C DeMarco
Apr 28, 2006·The British Journal of Radiology·A H de VriesJ Stoker
Jun 20, 2006·Scandinavian Journal of Gastroenterology. Supplement·Yung NioJaap Stoker
Dec 17, 2008·Expert Review of Gastroenterology & Hepatology·Rizwan Aslam, Judy Yee
Apr 25, 2007·Cancer Investigation·Nikhil Deshpande, David S Weinberg
Feb 25, 2014·Seminars in Oncology Nursing·Sherri G HomanJane M Armer
Oct 8, 2013·Techniques in Gastrointestinal Endoscopy·Philip S Schoenfeld, Jonathan Cohen
Feb 5, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Douglas K Rex
Sep 29, 2011·Gastrointestinal Endoscopy·Deborah A FisherJason A Dominitz
Mar 1, 2011·Gastrointestinal Endoscopy·Dawn L FrancisMichael Wallace
May 11, 2010·Gastrointestinal Endoscopy Clinics of North America·Jonathan A Rosenberg, David T Rubin
Dec 17, 2009·Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes·Patrick A HeinPatrik Rogalla
Nov 26, 2009·Gastroenterology·Claude Matuchansky
Aug 5, 2008·Gastrointestinal Endoscopy Clinics of North America·Michael J Krier, Pankaj Jay Pasricha
Dec 7, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Silke WalleserVal Gebski
Aug 19, 2007·Gastroenterología y hepatología·María Chaparro SánchezJavier P Gisbert
May 16, 2007·Radiologic Clinics of North America·Luis A LanderasJudy Yee
Jun 9, 2007·Gastrointestinal Endoscopy Clinics of North America·Lev GinzburgJonathan Cohen
Mar 14, 2007·The American Journal of Medicine·Alan S Rosman, Mark A Korsten
Dec 23, 2006·Gastrointestinal Endoscopy·Douglas K Rex
Dec 13, 2006·Radiologic Clinics of North America·Marc J GollubTim Akhurst
Oct 20, 2006·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A PezzoliS Gullini
Dec 2, 2006·Academic Radiology·Suzanne M Frentz, Ronald M Summers

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