Computed tomographic colonography to screen for colorectal cancer, extracolonic cancer, and aortic aneurysm: model simulation with cost-effectiveness analysis

Archives of Internal Medicine
Cesare HassanSergio Morini

Abstract

In addition to detecting colorectal neoplasia, abdominal computed tomography (CT) with colonography technique (CTC) can also detect unsuspected extracolonic cancers and abdominal aortic aneurysms (AAA).The efficacy and cost-effectiveness of this combined abdominal CT screening strategy are unknown. A computerized Markov model was constructed to simulate the occurrence of colorectal neoplasia, extracolonic malignant neoplasm, and AAA in a hypothetical cohort of 100,000 subjects from the United States who were 50 years of age. Simulated screening with CTC, using a 6-mm polyp size threshold for reporting, was compared with a competing model of optical colonoscopy (OC), both without and with abdominal ultrasonography for AAA detection (OC-US strategy). In the simulated population, CTC was the dominant screening strategy, gaining an additional 1458 and 462 life-years compared with the OC and OC-US strategies and being less costly, with a savings of $266 and $449 per person, respectively. The additional gains for CTC were largely due to a decrease in AAA-related deaths, whereas the modeled benefit from extracolonic cancer downstaging was a relatively minor factor. At sensitivity analysis, OC-US became more cost-effective only when th...Continue Reading

Citations

May 3, 2012·European Radiology·Margriet C de HaanJaap Stoker
Jun 23, 2009·AJR. American Journal of Roentgenology·Cynthia H McColloughJoel G Fletcher
Feb 25, 2010·World Journal of Gastroenterology : WJG·Otto Schiueh-Tzang Lin
Jul 29, 2010·Journal of the National Cancer Institute·Amy B KnudsenAnn G Zauber
Mar 24, 2011·AJR. American Journal of Roentgenology·Amy Berrington de GonzálezChristine D Berg
May 12, 2011·Cardiology Research and Practice·Abdullah JibawiSyed Waquar Yusuf
Apr 22, 2009·AJR. American Journal of Roentgenology·Perry J PickhardtDavid H Kim
Feb 23, 2010·AJR. American Journal of Roentgenology·Cody J BoyceJ Louis Hinshaw
Aug 24, 2010·AJR. American Journal of Roentgenology·Ganesh R VeerappanRoy K H Wong
Oct 23, 2010·AJR. American Journal of Roentgenology·Fouad J MoawadBrooks D Cash
Sep 26, 2012·International Journal of Technology Assessment in Health Care·Paul HanlyLinda Sharp
Dec 26, 2008·Abdominal Imaging·Franco IafrateAndrea Laghi
Jan 14, 2010·European Radiology·Perry J PickhardtDavid H Kim
Nov 1, 2008·Expert Opinion on Medical Diagnostics·Koichi NagataHiroyuki Yoshida
Dec 4, 2013·Journal of the American College of Radiology : JACR·Abraham H Dachman, Judy Yee
Dec 28, 2010·The Surgical Clinics of North America·Ancil K PhilipBruce Harms
May 11, 2010·Gastrointestinal Endoscopy Clinics of North America·Perry J Pickhardt, David H Kim
May 11, 2010·Gastrointestinal Endoscopy Clinics of North America·Judy YeeBenjamin Yeh
Mar 23, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Perry J PickhardtCesare Hassan
Sep 10, 2015·Abdominal Imaging·Bruce PyensonMichele Berrios
May 19, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Perry J PickhardtNeil Binkley
Oct 24, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Kyu-Tae HanEun-Cheol Park
May 23, 2015·AJR. American Journal of Roentgenology·Andrew E MorganPeter N Kolettis
Dec 11, 2014·Digestive Diseases and Sciences·Perry J Pickhardt
Mar 26, 2011·Academic Radiology·Carolyn M RutterPari V Pandharipande
Dec 30, 2008·Journal of the American College of Radiology : JACR·Lincoln L Berland
Apr 28, 2009·Journal of the American College of Radiology : JACR·Jean-Eric TarrideRon Goeree

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aortic Aneurysm

An aortic aneurysm is the weakening and bulging of the blood vessel wall in the aorta. This causes dilatation of the aorta, which is usually asymptomatic but carries the risk of rupture and hemorrhage. Find the latest research on aortic aneurysms here.

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Cardiac Aneurysm

Aneurysm refers to a bulge of the wall or lining of a vessel commonly occurring in the blood vessels at the base of the septum or within the aorta. In the heart, it usually arises from a patch of weakened tissue in a ventricular wall, which swells into a bubble filled with blood. Discover the latest research on cardiac aneurysm here.

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.