Computed tomography analysis of airway dimensions and lung density in patients with sarcoidosis

Respiration; International Review of Thoracic Diseases
Tomohiro HandaM Mishima

Abstract

It was previously reported that visual scores of the lung opacities were associated with lung function in patients with sarcoidosis. However, there are no reports on the evaluation of airway dimensions or lung density by computed tomography (CT) in sarcoidosis patients. The aim of this study was to investigate whether airway dimensions and lung densities assessed by CT associate with pulmonary function in patients with sarcoidosis. CT scanning was performed in 43 sarcoidosis patients and lung densities were measured using in-house software. Means and standard deviations of lung density, kurtosis and skewness of lung density histograms were calculated. Tracheal area and airway wall area/total airway area (WA%) of the right apical bronchus were also measured. Pulmonary function tests were performed on the same day. Increased standard deviation of lung density and decreased kurtosis and skewness of lung density histograms were all associated with decreased total lung capacity, vital capacity and diffusion capacity. Increased standard deviation of lung density was also associated with decreased percentages of forced expiratory volume in 1 s and peak expiratory flow (%PEF). There was a positive correlation between tracheal area corr...Continue Reading

Citations

Jul 21, 2010·Current Opinion in Pulmonary Medicine·Johny A Verschakelen
Nov 16, 2011·Expert Review of Respiratory Medicine·Adam S Morgenthau, Alvin S Teirstein
Aug 14, 2012·Academic Radiology·Jiantao PuDavid Gur

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