Computed tomography assessment of exogenous surfactant-induced lung reaeration in patients with acute lung injury.

Critical Care : the Official Journal of the Critical Care Forum
Qin LuJean-Jacques Rouby

Abstract

Previous randomized trials failed to demonstrate a decrease in mortality of patients with acute lung injury treated by exogenous surfactant. The aim of this prospective randomized study was to evaluate the effects of exogenous porcine-derived surfactant on pulmonary reaeration and lung tissue in patients with acute lung injury and acute respiratory distress syndrome (ALI/ARDS). Twenty patients with ALI/ARDS were studied (10 treated by surfactant and 10 controls) in whom a spiral thoracic computed tomography scan was acquired before (baseline), 39 hours and 7 days after the first surfactant administration. In the surfactant group, 3 doses of porcine-derived lung surfactant (200 mg/kg/dose) were instilled in both lungs at 0, 12 and 36 hours. Each instillation was followed by recruitment maneuvers. Gas and tissue volumes were measured separately in poorly/nonaerated and normally aerated lung areas before and seven days after the first surfactant administration. Surfactant-induced lung reaeration was defined as an increase in gas volume in poorly/non-aerated lung areas between day seven and baseline compared to the control group. At day seven, surfactant induced a significant increase in volume of gas in poorly/non-aerated lung are...Continue Reading

References

Mar 1, 1995·American Journal of Respiratory and Critical Care Medicine·P SandifordD P Schuster
Aug 1, 1993·Journal of Biomechanical Engineering·D Halpern, J B Grotberg
Nov 1, 1993·The American Review of Respiratory Disease·J F Lewis, L McCaig
Aug 1, 1996·American Journal of Respiratory and Critical Care Medicine·M D HenryJ M Davis
Apr 1, 1997·American Journal of Respiratory and Critical Care Medicine·T J GregoryA J Gold
Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine·S R VieiraJ J Rouby
May 12, 2000·American Journal of Respiratory and Critical Care Medicine·M TorresinV P Carnielli
Jun 14, 2000·American Journal of Respiratory and Critical Care Medicine·L M MalbouissonJ J Rouby
May 18, 2001·Intensive Care Medicine·L M MalbouissonJ J Rouby
May 24, 2001·American Journal of Respiratory and Critical Care Medicine·L M MalbouissonUNKNOWN CT Scan ARDS Study Group
Jun 19, 2001·The European Respiratory Journal·R A VeldhuizenL McCaig
Oct 31, 2002·Pulmonary Pharmacology & Therapeutics·Cordula StammeStefan Uhlig
Mar 22, 2003·American Journal of Respiratory and Critical Care Medicine·Roger G SpraggJames J Marsh
Jun 29, 2004·Anesthesiology·Jean-Jacques RoubyQin Lu
Aug 27, 2004·The New England Journal of Medicine·Roger G SpraggWerner Seeger
Jan 27, 2005·JAMA : the Journal of the American Medical Association·Douglas F WillsonUNKNOWN Pediatric Acute Lung Injury and Sepsis Investigators
Apr 30, 2005·Journal of Perinatology : Official Journal of the California Perinatal Association·Gautham K Suresh, Roger F Soll
Mar 18, 2006·Critical Care : the Official Journal of the Critical Care Forum·Warren J DavidsonNajib T Ayas
Jun 10, 2008·Intensive Care Medicine·Andreas W ReskeMatthias Seiwerts
Mar 20, 2009·International Archives of Allergy and Immunology·Veit J ErpenbeckJens M Hohlfeld
Mar 31, 2009·The Journal of Thoracic and Cardiovascular Surgery·Bart P van PutteJozef Kesecioglu
Aug 4, 2009·Methods and Findings in Experimental and Clinical Pharmacology·Andreas WemhönerLudwig Gortner
Aug 29, 2009·American Journal of Respiratory and Critical Care Medicine·Jozef KeseciogluBurkhard Lachmann

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Citations

Nov 19, 2013·Critical Care : the Official Journal of the Critical Care Forum·Davide ChiumelloSilvia Coppola
Aug 26, 2010·Critical Care : the Official Journal of the Critical Care Forum·Marcus J Schultz
Aug 29, 2012·Critical Care Research and Practice·Alexey A SmetkinMikhail Y Kirov
Apr 10, 2015·Chest·Douglas F WillsonEdmund E Egan
May 24, 2011·Journal of Cardiothoracic and Vascular Anesthesia·Marcin KarczBurkhard Lachmann
Sep 13, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jolanta E Damas, Max H Cake
Dec 7, 2011·Current Opinion in Critical Care·Giacomo BellaniAntonio Pesenti
Jun 30, 2019·The European Respiratory Journal·Davide ChiumelloPaolo Navalesi
Jul 13, 2013·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Douglas F WillsonUNKNOWN Pediatric Acute Lung and Sepsis Investigators Network
Oct 28, 2020·Intensive Care Medicine Experimental·Robert QaqishLorenzo Del Sorbo

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Methods Mentioned

BETA
bronchoalveolar lavage

Software Mentioned

Lungview
Sigmastat

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