Abstract
To describe the computed tomography (CT) findings of pulmonary extensively drug-resistant tuberculosis (XDR-TB) in non-HIV-infected patients and to compare them with those of non-XDR multidrug-resistant tuberculosis (MDR-TB). Retrospective review of microbiological results and drug-susceptibility tests of 260 non-HIV-infected patients who had been diagnosed with pulmonary MDR-TB from 1994 to 2005 revealed that 47 patients had XDR-TB, whereas the other 213 patients had non-XDR MDR-TB. Twenty of the 47 XDR-TB patients and 85 of the 213 non-XDR MDR-TB patients with available CT examinations were included in this study. Two radiologists reviewed the CT studies in consensus for the presence and extent of micronodules, tree-in-bud appearance, lobular consolidation (<2 cm), consolidation, cavity, bronchiectasis, emphysema, pleural effusion, lymphadenopathy, bronchopleural fistula, and empyema. We then compared the CT features of XDR-TB with those of non-XDR MDR-TB. Micronodules and tree-in-bud appearance were the most frequent CT abnormalities and were seen in all XDR-TB patients (100%). Consolidations, cavities, bronchiectasis, and lobular consolidations were found in 85%, 85%, 80%, and 70% of XDR-TB patients, respectively. The exten...Continue Reading
References
Mar 1, 1993·Radiology·J G ImS Noma
Apr 1, 1996·Thorax·O N HatipoğluC Yüksel
Aug 1, 1997·American Journal of Respiratory and Critical Care Medicine
Oct 25, 2000·Journal of Computer Assisted Tomography·J Y LeeT S Kim
Oct 13, 2006·The New England Journal of Medicine·David A J MooreJon S Friedland
Feb 16, 2007·The New England Journal of Medicine·Mario C Raviglione, Ian M Smith
Apr 27, 2007·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·N VezirisA Aubry
Jun 8, 2007·Emerging Infectious Diseases·N Sarita ShahJ Peter Cegielski
Aug 11, 2007·The European Respiratory Journal·G B MiglioriUNKNOWN SMIRA/TBNET Study Group
Oct 31, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hye-Ryoun KimJae-Joon Yim
Aug 9, 2008·The New England Journal of Medicine·Carole D MitnickMercedes C Becerra
Aug 9, 2008·The New England Journal of Medicine·Mario C Raviglione
Nov 27, 2009·Journal of Computer Assisted Tomography·Jeong A YeomYeong Dae Kim
Citations
Jul 5, 2011·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Ulaş BağcıDaniel J Mollura
May 31, 2014·Revue de pneumologie clinique·S Hantous-ZannadK Ben Miled-M'rad
Mar 27, 2015·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Anthony L ByrneGuy B Marks
May 8, 2016·Radiologic Clinics of North America·Carlos Santiago RestrepoAmy Mumbower
Jan 1, 2013·SpringerPlus·Sanghyeon KimJongyuk Lee
Jan 12, 2017·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Arun C NachiappanMark M Hammer
Jun 7, 2017·PloS One·Duo LiPingxin Lv
Oct 5, 2018·International Journal of Computer Assisted Radiology and Surgery·Stefan JaegerGeorge Thoma