Abstract
Microenvironment changes had occurred in the metastatic organs before the arriving of the metastatic tumor cells. In this study, we evaluated the effectiveness of computed tomography (CT) images in quantifying the microenvironment changes in the premetastatic lung under both laboratory and clinical conditions. Free-breathing Balb/c mice underwent micro-CT repeatedly after the implantation of 4T1 breast tumor. CT-derived indicators (aerated lung volume, lung tissue volume, total lung volume, mean lung density, and the ratio of aerated lung volume to the total lung volume) were quantified. Hematoxylin-eosin staining was used to display the microenvironment changes in premetastatic lung. Moreover, we examined healthy adult women, adult women with histopathologically confirmed primary breast cancer, and adult women with histopathologically confirmed primary breast cancer and lung metastases in our institution to test whether the indicators derived from lung CT images changed with the growth of breast cancer. In 4T1 tumor-bearing mice, lung density is increased before lung masses can be recognized on CT images and is correlated with the severity of inflammation in the lung microenvironment. In primary breast tumor-bearing patients, ...Continue Reading
References
Nov 1, 1995·Journal of Applied Physiology·H O CoxsonJ C Hogg
Aug 30, 2000·Nature·C M PerouD Botstein
Dec 13, 2005·Nature·Rosandra N KaplanDavid Lyden
Mar 25, 2009·Nature Reviews. Cancer·Bethan Psaila, David Lyden
Nov 6, 2009·Physics in Medicine and Biology·X ArtaechevarriaA Muñoz-Barrutia
Jun 25, 2010·European Radiology·Xabier ArtaechevarriaCarlos Ortiz-de-Solorzano
Jul 16, 2010·Cancer Research·Hannah H YanLi Yang
Oct 21, 2011·European Radiology·Daniel ChongJonathan G Goldin
Apr 13, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Monica ShokeenCarolyn J Anderson
Sep 25, 2012·Nature·UNKNOWN Cancer Genome Atlas Network
May 3, 2013·Cancer Metastasis Reviews·Jaclyn SceneayAndreas Möller
Jun 21, 2013·PloS One·Firdaus A A Mohamed HoeseinPieter Zanen
Sep 17, 2013·Respiratory Medicine·Firdaus A A Mohamed HoeseinPim A de Jong
Feb 26, 2014·Respiratory Research·Reza KarimiCarl Magnus Sköld
Mar 31, 2015·Molecular Therapy : the Journal of the American Society of Gene Therapy·Shin-Ae KangTakemi Tanaka
Feb 26, 2016·Theranostics·Zhaoling DanYaping Li
Nov 16, 2016·Cancer Cell·Yang Liu, Xuetao Cao
Nov 22, 2016·Laboratory Investigation; a Journal of Technical Methods and Pathology·Eyra MarienGreetje Vande Velde
Mar 18, 2017·Nature Reviews. Cancer·Héctor PeinadoDavid Lyden
Apr 22, 2017·Oncotarget·Qi WuShengrong Sun
Jul 27, 2017·Theranostics·Michel EisenblaetterTony Ng
Dec 3, 2017·Cancer Discovery·Oliver M T PearceFrances R Balkwill
Feb 24, 2018·Cancer Medicine·Weikai XiaoXiaoming Xie
Mar 28, 2018·Cancer Biology & Therapy·Liting JinXiaojiang Cui
Jun 9, 2018·European Radiology Experimental·Anton S BeckerAndreas Boss
May 11, 2019·International Journal of Molecular Sciences·Braeden Medeiros, Alison L Allan
Sep 26, 2019·Molecular Carcinogenesis·Ranran LiMingyong Han
Oct 31, 2019·Journal of the National Cancer Institute·Meenakshi AnuragMatthew J Ellis
Mar 14, 2020·European Radiology·Yana QiMingyong Han