Computed tomography texture analysis in patients with gastric cancer: a quantitative imaging biomarker for preoperative evaluation before neoadjuvant chemotherapy treatment.

Japanese Journal of Radiology
Aytul Hande YardimciOzgur Kilickesmez

Abstract

The aim of the study is to explore the role of computed tomography texture analysis (CT-TA) for predicting clinical T and N stages and tumor grade before neoadjuvant chemotherapy treatment in gastric cancer (GC) patients during the preoperative period. CT images of 114 patients with GC were included in this retrospective study. Following pre-processing steps, textural features were extracted using MaZda software in the portal venous phase. We evaluated and analyzed texture features of six principal categories for differentiating between T stages (T1,2 vs T3,4), N stages (N+ vs N-) and grades (low-intermediate vs. high). Classification was performed based on texture parameters with high model coefficients in linear discriminant analysis (LDA). Dimension-reduction steps yielded five textural features for T stage, three for N stage and two for tumor grade. The discriminatory capacities of T stage, N stage and tumor grade were 90.4%, 81.6% and 64.5%, respectively, when LDA algorithm was employed. CT-TA yields potentially useful imaging biomarkers for predicting the T and N stages of patients with GC and can be used for preoperative evaluation before neoadjuvant treatment planning.

References

Oct 17, 2008·Computer Methods and Programs in Biomedicine·Piotr M SzczypińskiArtur Klepaczko
Apr 25, 2009·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Robert Michael Kwee, Thomas Christian Kwee
Feb 11, 2010·Advances in Health Sciences Education : Theory and Practice·Geoff Norman
May 16, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stephen R SmalleyJohn S Macdonald
Oct 25, 2012·Insights Into Imaging·Fergus DavnallVicky Goh
Apr 3, 2013·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Balaji Ganeshan, Kenneth A Miles
Aug 6, 2013·European Journal of Radiology·Ahmed Ba-SsalamahMarius E Mayerhoefer
Jun 23, 2015·Journal of Gastroenterology and Hepatology·Qingshan PeiXiaoping Zou
Dec 25, 2015·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Kaiyu SunJianbo Xu
May 10, 2016·Lancet·Eric Van CutsemHans Prenen
Jun 28, 2016·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·UNKNOWN Japanese Gastric Cancer Association
Sep 21, 2016·Best Practice & Research. Clinical Gastroenterology·Florian Lordick, Masanori Terashima
Jan 24, 2017·Medical Physics·Muhammad Shafiq-Ul-HassanEduardo Gerardo Moros
Mar 11, 2017·Japanese Journal of Radiology·Daisuke TsurumaruHiroshi Honda
Jun 22, 2018·Clinical and Translational Radiation Oncology·A SchernbergF Huguet

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.