PMID: 374576Jan 1, 1979Paper

Computer aided analysis of chromatin network and basophil color for differentiation of mononuclear peripheral blood cells

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
H HarmsV ter Meulen

Abstract

Computer aided differentiation of plasmoblasts, Pfeiffer cells, immunoblasts, lymphocytes and centrocytes is achieved with the parameters of chromatin network arrangement and structure, and multispectral cytoplasm color. The digital methods involve: (a) segmenting the nuclear image into topographic sections and analyzing the optical density distribution from the chromatin in these sections; (b) determining the nuclear structure with a 7 x 7 median filter, gradient filter and contour following algorithms; and (c) clustering two-dimensional chromatic data from panoptically stained cellular components. The parameters reported here are a subset of those needed for the automated diagnosis of many hematologic diseases especially the leukemias.

Citations

Jan 1, 1989·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·M BergmannH K Müller-Hermelink

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