PMID: 16617628Apr 19, 2006Paper

Computer-aided continuous drug infusion: setup and test of a mobile closed-loop system for the continuous automated infusion of insulin

IEEE Transactions on Information Technology in Biomedicine : a Publication of the IEEE Engineering in Medicine and Biology Society
Ralf DuddeRainer Hintsche

Abstract

For a diabetes mellitus patient, tight control of glucose level is essential. Results are reported of an investigation of the suitability of existing wearable continuous insulin infusors controlled and adjusted by a control algorithm using continuous glucose measurements as input to perform the functionality of an artificial pancreas. Special attention was given to the development of a continuous glucose monitor and to evaluate which quality of input data is necessary for the control algorithm. In clinical trials, it was found that for patients in a controlled environment an autonomously regulating control algorithm leads to an improved adjustment of patient glucose values and less overall insulin infusion as compared with the best fixed preprogrammed insulin infusion profiles of standard pump therapy. For the limited number of cases studied here, functionality of the control algorithm could tolerate some delay between the actual glucose values in the patient interstitial fluid and the algorithm input of up to 30 min. A quasicontinuous glucose measurement delivering actual glucose values every 5-10 min seems to be suited to control an artificial pancreas.

References

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Oct 26, 2005·Biosensors & Bioelectronics·G PiechottaR Hintsche

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Citations

Apr 14, 2007·Analytical and Bioanalytical Chemistry·Venkata Radhakrishna Kondepati, H Michael Heise
Nov 7, 2009·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Masami HoshinoMotohiro Sakai
Apr 26, 2008·International Journal of Telemedicine and Applications·Daisuke TakahashiMichael Lewis
Apr 24, 2012·Journal of Neuroengineering and Rehabilitation·Shyamal PatelMary Rodgers
Jun 21, 2008·International Journal of Telemedicine and Applications·Daisuke TakahashiFei Hu
Sep 7, 2007·Advanced Drug Delivery Reviews·Erhard Haus
Apr 26, 2011·Optimal Control Applications & Methods·Mihalis G MarkakisVasilis Z Marmarelis
Jul 18, 2008·IEEE Transactions on Information Technology in Biomedicine : a Publication of the IEEE Engineering in Medicine and Biology Society·Enrique J GómezAlberto de Leiva
Jan 1, 2007·Journal of Diabetes Science and Technology·David C Klonoff
Sep 1, 2008·Journal of Diabetes Science and Technology·Eyal DassauFrancis J Doyle

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